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Anti-Chido/Rodgers antibodies in a patient with infectious disease / Anticuerpos anti-Chido/Rodgers en paciente con enfermedad infecciosa
Gomes Vizzoni, Alexandre; Medeiros da Silva, Flavia Regina; Barreto Bokel, Joanna Paes.
  • Gomes Vizzoni, Alexandre; Evandro Chagas National Institute of Infectious Diseases. BR
  • Medeiros da Silva, Flavia Regina; Evandro Chagas National Institute of Infectious Diseases. BR
  • Barreto Bokel, Joanna Paes; Evandro Chagas National Institute of Infectious Diseases. BR
Rev. cuba. hematol. inmunol. hemoter ; 38(2): e1561, abr.-jun. 2022. graf
Article in English | LILACS, CUMED | ID: biblio-1408448
ABSTRACT

Introduction:

Red cell alloimmunization is an immune response against foreign red cell antigens, usually occurring due to sensibilization in blood transfusions and pregnancies. The Chido (Ch) and Rodgers (Rg) antigens are present in about 96-98 percent of the population in general. Patients who have antibodies against antigens of high frequency in the population are a problem for transfusion medicine.

Objectives:

To describe the case of a patient diagnosed with AIDS and invasive cancer of the rectum with a recent hospitalization for lower gastrointestinal bleeding and anemia with the presence of anti-Ch and anti-Rg and the difficulties and solutions found for handling the case. Case presentation Anti-Ch and anti-Rg have not been found to cause a hemolytic transfusion reaction (HTR) or hemolytic disease of the fetus and newborn (HDFN). However, the clinical presentation and laboratory findings including the immunohematological workups concerning the reaction are discussed, with a special emphasis on the benefit of identifying such an antibody and providing a compatible blood unit for transfusion support of the patient.

Conclusions:

When an antibody against a high-frequency erythrocyte antigen is identified in African or American-descent, anti-Ch or anti-Rg should be considered and that transfusion tests should not be delayed due to its clinical importance(AU)
RESUMEN

Introducción:

La aloinmunización de glóbulos rojos es una respuesta inmune frente a antígenos de glóbulos rojos extraños, que pueden ocurrir por sensibilización en transfusiones de sangre y embarazos. Los antígenos Chido (Ch) y Rodgers (Rg) están presentes en aproximadamente el 96-98 por ciento de la mayoría de la población. Los pacientes que tienen anticuerpos contra antígenos de alta frecuencia poblacional son un problema para la medicina transfusional.

Objetivos:

Describir caso de un paciente diagnosticado de AIDS y cáncer invasivo de recto con hospitalización reciente por hemorragia digestiva baja y anemia con presencia de anti-Ch y anti-Rg y las dificultades y soluciones encontradas para el manejo del caso. Presentación de caso No se ha encontrado que Anti-Ch y anti-Rg causen reacciones hemolíticas transfusionales y enfermedad hemolítica del recién nacido. Sin embargo, se discuten la presentación clínica y los hallazgos de laboratorio, incluidos los estudios inmunohematológicos con respecto a la reacción, con especial énfasis en el beneficio de identificar dicho anticuerpo y obtener una unidad de sangre para transfusión que respalde al paciente con respecto a proporcionar una unidad compatible.

Conclusiones:

Cuando se identifica anticuerpos contra un antígeno eritrocitario de alta frecuencia, en afrodescendientes o americanos, se deben considerar Anti-Ch o anti-Rg y no retrasar las pruebas de transfusión por su importancia clínica(AU)
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Rectal Neoplasms / Blood Transfusion / Communicable Diseases / Acquired Immunodeficiency Syndrome / Erythroblastosis, Fetal / Transfusion Medicine / Anemia Type of study: Prognostic study Limits: Humans Language: English Journal: Rev. cuba. hematol. inmunol. hemoter Journal subject: Allergy and Immunology / Hematology Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Evandro Chagas National Institute of Infectious Diseases/BR

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Full text: Available Index: LILACS (Americas) Main subject: Rectal Neoplasms / Blood Transfusion / Communicable Diseases / Acquired Immunodeficiency Syndrome / Erythroblastosis, Fetal / Transfusion Medicine / Anemia Type of study: Prognostic study Limits: Humans Language: English Journal: Rev. cuba. hematol. inmunol. hemoter Journal subject: Allergy and Immunology / Hematology Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Evandro Chagas National Institute of Infectious Diseases/BR