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Clinical-biochemical and Fibroelastometric Results of the Mare's Milk Application in Non-Alcoholic Steathepatitis / Resultados clínico-bioquímicos y fibroelastométricos de la aplicación de la leche de yegua en la esteatohepatitis no alcohólica
Bimbetov, Bakytzhan; Shanazarov, Nasrulla; Aitbaeva, Saule; Bakytzhanuly, Abay; Utepbergenova, Gulmira.
  • Bimbetov, Bakytzhan; The Medical Centre Hospital of the President's Affairs Administration of the Republic of Kazakhstan. KZ
  • Shanazarov, Nasrulla; The Medical Centre Hospital of the President's Affairs Administration of the Republic of Kazakhstan. KZ
  • Aitbaeva, Saule; JSC Medical University of Astana. Nur-Sultan. KZ
  • Bakytzhanuly, Abay; JSC Medical University of Astana. Nur-Sultan. KZ
  • Utepbergenova, Gulmira; Khoja Akhmet Yassawi International Kazakh-Turkish University. KZ
Article in Spanish | LILACS, CUMED | ID: biblio-1408656
RESUMEN

Introduction:

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world, representing the hepatic component of metabolic syndrome, and currently affects an average of 20-33 percent of the adult population. Non-alcoholic steatohepatitis (NASH) is a severe form of NAFLD and is a consequence of overweight, obesity, and metabolic syndrome.

Objective:

The study aimed to evaluate the effectiveness of the use of freeze-dried mare's milk in NASH.

Methods:

Clinical-biochemical, ultrasound, and fibroelastometric research methods were used in NASH patients receiving mare's milk in comparison with the control groups.

Results:

The result of the study demonstrates noticeable gain not only in the clinical symptoms of the disease but also in the laboratory and instrumental indicators, as well as health improvement and a decrease in symptoms of concomitant pathology. Taking mare's milk not only normalized liver biochemical parameters but also decreased cholesterol metabolism (total cholesterol, LDL, TG), the degree of liver steatosis, and existing hepatomegaly declined too. This pleiotropic effect of mare's milk points to the pathogenetic feasibility for the use of Saumal in NAFLD, including NASH.

Conclusions:

Addressing the problems of healthy nutrition in NASH, mare's milk can be considered as a pathogenetically justified, highly effective, and affordable natural therapeutic and prophylactic agent. The value of the product is determined by its multicomponent balanced qualitative composition. Hepatoprotective, hypocholesterolemic, and lipotropic properties of mare's milk in this pathology are marked(AU)
ABSTRACT

Introducción:

La enfermedad del hígado graso no alcohólico es la enfermedad hepática más común en el mundo, representa el componente hepático del síndrome metabólico y actualmente afecta a un promedio de 20 a 33 por ciento de la población adulta. La esteatohepatitis no alcohólica es una forma grave de hígado graso no alcohólico y es una consecuencia del sobrepeso, la obesidad y el síndrome metabólico.

Objetivo:

Evaluar la efectividad del uso de leche de yegua liofilizada en hígado graso no alcohólico.

Métodos:

Se utilizaron métodos de investigación clínico-bioquímicos, ecográficos y fibroelastométricos en pacientes con hígado graso no alcohólico que recibieron leche de yegua en comparación con los grupos de control.

Resultados:

El resultado del estudio demuestra una ganancia notable no solo en los síntomas clínicos de la enfermedad, sino también en los indicadores de laboratorio e instrumentales, así como una mejora de la salud y una disminución de los síntomas de la enfermedad concomitante. La ingesta de leche de yegua no solo normalizó los parámetros bioquímicos del hígado, sino que también disminuyó el metabolismo del colesterol (colesterol total, LDL, TG), el grado de esteatosis hepática y la hepatomegalia existente también disminuyeron. Este efecto pleiotrópico de la leche de yegua apunta a la viabilidad patogénica del uso de Saumal en hígado graso no alcohólico, incluida la esteatohepatitis no alcohólica.

Conclusión:

Al abordar los problemas de una nutrición saludable en la enfermedad hígado graso no alcohólico, la leche de yegua se puede considerar como un agente terapéutico y profiláctico natural patogénicamente justificado, altamente efectivo y asequible. El valor del producto está determinado por su composición cualitativa equilibrada multicomponente. Las propiedades hepatoprotectoras, hipocolesterolémicas y lipotrópicas de la leche de yegua en esta enfermedad son marcadas(AU)
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Ultrasonography / Metabolic Syndrome / Non-alcoholic Fatty Liver Disease Type of study: Qualitative research Limits: Female / Humans / Male Language: Spanish Journal: Rev. cuba. med. gen. integr Journal subject: Medicine Year: 2021 Type: Article Affiliation country: Kazakhstan Institution/Affiliation country: JSC Medical University of Astana. Nur-Sultan/KZ / Khoja Akhmet Yassawi International Kazakh-Turkish University/KZ / The Medical Centre Hospital of the President's Affairs Administration of the Republic of Kazakhstan/KZ

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Full text: Available Index: LILACS (Americas) Main subject: Ultrasonography / Metabolic Syndrome / Non-alcoholic Fatty Liver Disease Type of study: Qualitative research Limits: Female / Humans / Male Language: Spanish Journal: Rev. cuba. med. gen. integr Journal subject: Medicine Year: 2021 Type: Article Affiliation country: Kazakhstan Institution/Affiliation country: JSC Medical University of Astana. Nur-Sultan/KZ / Khoja Akhmet Yassawi International Kazakh-Turkish University/KZ / The Medical Centre Hospital of the President's Affairs Administration of the Republic of Kazakhstan/KZ