Significant Rise in SARS-CoV-2 Reinfection Rate in Vaccinated Hospital Workers during the Omicron Wave: A Prospective Cohort Study
Rev. invest. clín
;
74(4): 175-180, Jul.-Aug. 2022. tab, graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1409579
ABSTRACT
ABSTRACT Background:
Relatively low SARS-CoV-2 reinfection rates have been reported in vaccinated individuals, but updates considering the Omicron variant are lacking.Objective:
The objective of the study was to provide a current estimate of the SARS-CoV-2 reinfection rate in a highly immunized population.Methods:
A prospective cohort of Mexican hospital workers was followed (March 2020-February 2022). Reinfection was defined as the occurrence of two or more episodes of COVID-19 separated by a period of ≥ 90 days without symptoms. The reinfection rate was calculated as the number of reinfection episodes per 100,000 persons per day.Results:
A total of 3732 medical consultations were provided to 2700 workers, of whom 1388 (51.4%) were confirmed COVID-19 cases. A total of 73 reinfection cases were identified, of whom 71 (97.3%) had completed their primary vaccination series and 22 (30.1%) had had a booster dose before the second episode. The overall reinfection rate was 23.1 per 100,000 persons per day (as compared to a rate of 1.9 per 100,000 persons per day before the Omicron wave).Conclusions:
The SARS-CoV-2 reinfection rate rose significantly during the Omicron wave despite a high primary vaccination coverage rate. Almost one-third of reinfected workers had a vaccine booster ≥ 14 days before the last COVID-19 episode.
Full text:
Available
Index:
LILACS (Americas)
Type of study:
Etiology study
/
Observational study
Language:
English
Journal:
Rev. invest. clín
Journal subject:
Medicine
Year:
2022
Type:
Article
Affiliation country:
Mexico
Institution/Affiliation country:
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán/MX
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