In-hospital severe COVID-19 in a philanthropic tertiary hospital setting: is asthma a concern? A retrospective study
São Paulo med. j
;
140(5): 651-657, Sept.-Oct. 2022. tab, graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1410214
ABSTRACT
ABSTRACT BACKGROUND:
The frequency of coronavirus disease 2019 (COVID-19) cases among asthmatics has been reported to be reduced. However, the findings regarding the association between asthma and the risk of severe COVID-19 have been divergent.OBJECTIVE:
To investigate whether asthma is associated with a reduced risk of development of severe COVID-19. DESIGN ANDSETTING:
Retrospective analysis on COVID-19 surveillance databases at two tertiary-level hospitals in São Paulo, Brazil.METHODS:
The medical records of patients hospitalized due to COVID-19 between March and August 2020 were reviewed in accordance with the clinical, laboratorial, radiological and epidemiological criteria for COVID-19, and for comorbidities.RESULTS:
Among the adult patients included (> 18 years of age) there were 52 asthmatics and 1,318 non-asthmatics. Their median ages and interquartile ranges (IQR) were, respectively, 54 (41-69) and 60 (44-72) years. At least one comorbidity was seen in 73% of asthmatics and 56% of the non-asthmatics. Among the asthmatics, most presented mild asthma (92%) and the prevalence of chronic obstructive pulmonary disease (COPD) was high (27%). The asthmatics presented an unadjusted odds ratio (OR) for severe COVID-19 of 0.89 (95% confidence interval, CI 0.5-1.56); and OR 0.88 (95% CI 0.5 -1.68) after multivariable adjustment. Age > 60 years, male sex, hypertension, diabetes, cancer and homelessness were covariates associated with increased odds for severe COVID-19. Kaplan-Meier estimated survival over hospitalization of up to 30 days did not differ between the groups (log-rank P = 0.09).CONCLUSIONS:
The association between asthma and decreased risk of severe COVID-19 or increased survival was statistically non-significant.
Full text:
Available
Index:
LILACS (Americas)
Type of study:
Observational study
/
Risk factors
Language:
English
Journal:
São Paulo med. j
Journal subject:
Cirurgia Geral
/
Cincia
/
Ginecologia
/
Medicine
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Year:
2022
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Faculdade de Ciências Médicas da Santa Casa de São Paulo (FCMSCSP)/BR
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