Could outcomes of intracranial aneurysms be better predict using serum creatinine and glomerular filtration rate?
Acta cir. bras
;
37(1): e370107, 2022. ilus, tab, graf
Article
in English
| LILACS, VETINDEX
| ID: biblio-1413349
ABSTRACT
Purpose:
To analyze the role of serum creatinine levels as a biomarker of intracranial aneurysm outcomes.Methods:
This is a prospective analysis of outcomes of patients with intracranial aneurysm. One hundred forty-seven patients with serum creatinine at admission and 6 months follow up were included. Linear and logistic regressions were used to analyze the data. Modified Rankin scale (mRS) was used to assess outcome.Results:
Creatinine level was not directly related to aneurysm outcome nor aneurysm rupture (p > 0.05). However, patients with a glomerular filtration rate (GFR) lower than 72.50 mL·min1 had an odds ratio (OR) of 3.049 (p = 0.006) for worse outcome. Similarly, aneurysm rupture had an OR of 2.957 (p = 0.014) for worse outcomes. Stepwise selection model selected 4 variables for outcomes prediction serum creatinine, sex, hypertension and treatment. Hypertensive patients had, on average, an increase in 0.588 in mRS (p = 0.022), while treatment with microsurgery had a decrease in 0.555 (p = 0.038).Conclusions:
Patients with higher GFR had better outcomes after 6 months. Patients with higher GFR had better outcomes after 6 months. Creatinine presented an indirect role in GFR values and should be included in models for outcome prediction.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Intracranial Aneurysm
/
Creatinine
/
Glomerular Filtration Rate
Type of study:
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Acta cir. bras
Year:
2022
Type:
Article
Institution/Affiliation country:
Centro Universitário Saúde ABC/BR
/
Universidade de São Paulo/BR
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