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Could outcomes of intracranial aneurysms be better predict using serum creatinine and glomerular filtration rate?
Rabelo, Nícollas Nunes; Pipek, Leonardo Zumerkorn; Nascimento, Rafaela Farias Vidigal; Telles, João Paulo Mota; Barbato, Natalia Camargo; Coelho, Antônio Carlos Samaia da Silva; Barbosa, Guilherme Bitencourt; Yoshikawa, Marcia Harumy; Teixeira, Manoel Jacobsen; Figueiredo, Eberval Gadelha.
  • Rabelo, Nícollas Nunes; Universidade de São Paulo. Department of Neurosurgery. São Paulo. BR
  • Pipek, Leonardo Zumerkorn; Universidade de São Paulo. Faculdade de Medicina. São Paulo. BR
  • Nascimento, Rafaela Farias Vidigal; Centro Universitário Saúde ABC. Faculdade de Medicina do ABC. Santo André. BR
  • Telles, João Paulo Mota; Universidade de São Paulo. Department of Neurosurgery. São Paulo. BR
  • Barbato, Natalia Camargo; Universidade de São Paulo. Faculdade de Medicina. São Paulo. BR
  • Coelho, Antônio Carlos Samaia da Silva; Universidade de São Paulo. Faculdade de Medicina. São Paulo. BR
  • Barbosa, Guilherme Bitencourt; Universidade de São Paulo. Faculdade de Medicina. São Paulo. BR
  • Yoshikawa, Marcia Harumy; Universidade de São Paulo. Faculdade de Medicina. São Paulo. BR
  • Teixeira, Manoel Jacobsen; Universidade de São Paulo. Department of Neurosurgery. São Paulo. BR
  • Figueiredo, Eberval Gadelha; Universidade de São Paulo. Department of Neurosurgery. São Paulo. BR
Acta cir. bras ; 37(1): e370107, 2022. ilus, tab, graf
Article in English | LILACS, VETINDEX | ID: biblio-1413349
ABSTRACT

Purpose:

To analyze the role of serum creatinine levels as a biomarker of intracranial aneurysm outcomes.

Methods:

This is a prospective analysis of outcomes of patients with intracranial aneurysm. One hundred forty-seven patients with serum creatinine at admission and 6 months follow up were included. Linear and logistic regressions were used to analyze the data. Modified Rankin scale (mRS) was used to assess outcome.

Results:

Creatinine level was not directly related to aneurysm outcome nor aneurysm rupture (p > 0.05). However, patients with a glomerular filtration rate (GFR) lower than 72.50 mL·min­1 had an odds ratio (OR) of 3.049 (p = 0.006) for worse outcome. Similarly, aneurysm rupture had an OR of 2.957 (p = 0.014) for worse outcomes. Stepwise selection model selected 4 variables for outcomes prediction serum creatinine, sex, hypertension and treatment. Hypertensive patients had, on average, an increase in 0.588 in mRS (p = 0.022), while treatment with microsurgery had a decrease in 0.555 (p = 0.038).

Conclusions:

Patients with higher GFR had better outcomes after 6 months. Patients with higher GFR had better outcomes after 6 months. Creatinine presented an indirect role in GFR values and should be included in models for outcome prediction.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Intracranial Aneurysm / Creatinine / Glomerular Filtration Rate Type of study: Prognostic study / Risk factors Limits: Humans Language: English Journal: Acta cir. bras Year: 2022 Type: Article Institution/Affiliation country: Centro Universitário Saúde ABC/BR / Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Intracranial Aneurysm / Creatinine / Glomerular Filtration Rate Type of study: Prognostic study / Risk factors Limits: Humans Language: English Journal: Acta cir. bras Year: 2022 Type: Article Institution/Affiliation country: Centro Universitário Saúde ABC/BR / Universidade de São Paulo/BR