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Brief communication: Vitamin D serum levels in American tegumentary leishmaniasis from an endemic area in Northeast Brazil
Figueiredo, Lorena Pinheiro; Cerqueira-Silva, Thiago; Magalhães, Andréa; Lago, Ednaldo Lima; Lessa, Marcus Miranda.
  • Figueiredo, Lorena Pinheiro; Universidade Federal da Bahia. Salvador. BR
  • Cerqueira-Silva, Thiago; Universidade Federal da Bahia. Salvador. BR
  • Magalhães, Andréa; Universidade Federal da Bahia. Serviço de Imunologia do Hospital Universitário Professor Edgard Santos. Salvador. BR
  • Lago, Ednaldo Lima; Universidade Federal da Bahia. Serviço de Imunologia do Hospital Universitário Professor Edgard Santos. Salvador. BR
  • Lessa, Marcus Miranda; Universidade Federal da Bahia. Serviço de Imunologia do Hospital Universitário Professor Edgard Santos. Salvador. BR
Braz. j. infect. dis ; 27(1): 102720, 2023. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1420728
ABSTRACT
Abstract Introduction The pathogenesis of cutaneous and mucosal leishmaniasis is associated with different immune responses. Vitamin D may modulate the immune system. Here we evaluate the association of vitamin D levels with the severity of the clinical forms of cutaneous and mucosal leishmaniasis. Methods We conducted an observational study evaluating the association between vitamin D levels, disease severity and therapeutic response in patients with cutaneous and mucosal leishmaniasis. Additionally, we conducted a cross-sectional study to compare vitamin D levels in patients with leishmaniasis and healthy subjects. Hypovitaminosis D was defined as a serum level of 25 (OH) D < 30 ng/mL. Results In patients with leishmaniasis, vitamin D serum levels were 38.5 ± 11.54 ng/mL, and 37.5 ± 10.43 ng/mL in healthy subjects The prevalence of hypovitaminosis D was 23.3% and 20.0%, respectively (p = 0.72). There was no correlation between vitamin D serum levels, disease severity, and healing time in the mucosal leishmaniasis group. Conclusion Vitamin D levels are not associated with neither susceptibility nor severity of tegumentary leishmaniasis.


Full text: Available Index: LILACS (Americas) Type of study: Observational study / Risk factors Country/Region as subject: South America / Brazil Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2023 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal da Bahia/BR

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Full text: Available Index: LILACS (Americas) Type of study: Observational study / Risk factors Country/Region as subject: South America / Brazil Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2023 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal da Bahia/BR