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T-type Ca2+ channels and their relationship with pre-neoplastic and neoplastic lesions in the human breast
Aguiar, F.; Rhana, P.; Bloise, E.; Nunes, C.B.; Rodrigues, A.L.; Ferreira, E..
  • Aguiar, F.; Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia. Belo Horizonte. BR
  • Rhana, P.; University of California Davis. Department of Physiology and Membrane Biology. Davis. US
  • Bloise, E.; Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Belo Horizonte. BR
  • Nunes, C.B.; Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Anatomia Patológica e Medicina Legal. Belo Horizonte. BR
  • Rodrigues, A.L.; Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte. BR
  • Ferreira, E.; Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia. Belo Horizonte. BR
Braz. j. med. biol. res ; 56: e11879, 2023. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1420747
ABSTRACT
The expression of T-type voltage-dependent Ca2+ channels (Cav3) has been previously observed in breast cancer, but their expression and subcellular localization were not evaluated in pre-neoplastic lesions. Therefore, this work aimed to evaluate protein expression and subcellular localization of T-type channel isoforms in human breast tissue samples. Protein expressions of CaV3.1, CaV3.2, and CaV3.3 were evaluated by immunohistochemistry in breast without alteration, in proliferative non-neoplastic lesions, and in neoplastic ductal epithelial lesions of the human breast. CaV3.1, CaV3.2, and CaV3.3 nuclear expressions were decreased in advanced stages of neoplastic transformation, whereas CaV3.1 and CaV3.2 cytoplasmic expression increased. Also, the decrease in nuclear expression was correlated with an increase in cytoplasmic expression for CaV3.1 isoform. The change in CaV3 protein expression and subcellular localization are consistent with the neoplastic transformation stages of mammary epithelial cells, evident in early neoplastic lesions, such as ductal carcinomas in situ. These results suggest a possible involvement of CaV3 in the carcinogenic processes and could be considered as a potential pharmacological target in new therapies for breast cancer treatment.


Full text: Available Index: LILACS (Americas) Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2023 Type: Article Affiliation country: Brazil / United States Institution/Affiliation country: Universidade Federal de Minas Gerais/BR / University of California Davis/US

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Full text: Available Index: LILACS (Americas) Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2023 Type: Article Affiliation country: Brazil / United States Institution/Affiliation country: Universidade Federal de Minas Gerais/BR / University of California Davis/US