Association of coronary artery calcium with heart rate variability in the Brazilian Longitudinal Study of Adult Health - ELSA-Brasil
Braz. j. med. biol. res
;
56: e12364, 2023. tab, graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1420754
ABSTRACT
Current data shows that the autonomic and vascular systems can influence each other. However, only a few studies have addressed this association in the general population. We aimed to investigate whether heart rate variability (HRV) was associated with coronary artery calcium (CAC) in a cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). We examined baseline data from 3138 participants (aged 35 to 74 years) without previous cardiovascular disease who underwent CAC score assessment and had validated HRV recordings. Prevalent CAC was defined as a CAC score>0, and HRV analyses were performed over 5-min segments. We detected CAC score>0 in 765 (24.4%) participants. Subgroup analyses in older participants (≥49 years) adjusted for sociodemographic and clinical variables revealed that CAC score>0 was associated with lower values of standard deviation of NN intervals (SDNN) (odds ratio [OR]=1.32; 95%CI 1.05,1.65), root mean square of successive differences between adjacent NN intervals (RMSSD) (OR=1.28; 95%CI 1.02,1.61), and low frequency (LF) (OR=1.53, 95%CI 1.21,1.92). Interaction analysis between HRV indices and sex in age-stratified groups revealed significant effect modification women showed increased OR for prevalent CAC in the younger group, while for men, the associations were in the older group. In conclusion, participants aged ≥49 years with low SDNN, RMSSD, and LF values were more likely to present prevalent CAC, suggesting a complex interaction between these markers in the pathogenesis of atherosclerosis. Furthermore, our results suggested that the relationship between CAC and HRV might be sex- and age-related.
Full text:
Available
Index:
LILACS (Americas)
Type of study:
Observational study
/
Risk factors
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2023
Type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Instituto Federal do Espírito Santo/BR
/
Universidade Federal do Espírito Santo/BR
/
Universidade Federal do Vale do São Francisco/BR
/
Universidade de São Paulo/BR
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