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Oxidative stress and inflammatory process in borderline personality disorder (BPD): a narrative review
Forte, A.R.C.C.; Lessa, P.H.C.; Chaves Filho, A.J.M.; Aquino, P.E.A. de; Brito, L.M.; Pinheiro, L.C.; Juruena, M.F.; Lucena, D.F. de; de Rezende, P.H.F.; de Vasconcelos, S.M.M..
  • Forte, A.R.C.C.; Universidade Federal do Ceará. Laboratório de Neuropsicofarmacologia. Fortaleza. BR
  • Lessa, P.H.C.; Universidade Federal do Amapá. Departamento de Ciências Biológicas e da Saúde (DCBS). Curso de Medicina. Macapá. BR
  • Chaves Filho, A.J.M.; Universidade Federal do Ceará. Laboratório de Neuropsicofarmacologia. Fortaleza. BR
  • Aquino, P.E.A. de; Universidade Federal do Ceará. Laboratório de Neuropsicofarmacologia. Fortaleza. BR
  • Brito, L.M.; Universidade Federal do Ceará. Laboratório de Neuropsicofarmacologia. Fortaleza. BR
  • Pinheiro, L.C.; Universidade Federal do Ceará. Laboratório de Neuropsicofarmacologia. Fortaleza. BR
  • Juruena, M.F.; Kings College London. Institute of Psychiatry, Psychology and Neuroscience. GB
  • Lucena, D.F. de; Universidade Federal do Ceará. Laboratório de Neuropsicofarmacologia. Fortaleza. BR
  • de Rezende, P.H.F.; Universidade Federal do Ceará. Laboratório de Neuropsicofarmacologia. Fortaleza. BR
  • de Vasconcelos, S.M.M.; Universidade Federal do Ceará. Laboratório de Neuropsicofarmacologia. Fortaleza. BR
Braz. j. med. biol. res ; 56: e12484, 2023. tab
Article in English | LILACS-Express | LILACS | ID: biblio-1420761
ABSTRACT
Borderline personality disorder (BPD) is a severe psychiatric condition that affects up to 2.7% of the population and is highly linked to functional impairment and suicide. Despite its severity, there is a lack of knowledge about its pathophysiology. Studies show genetic influence and childhood violence as factors that may contribute to the development of BPD; however, the involvement of neuroinflammation in BPD remains poorly investigated. This article aimed to explore the pathophysiology of BPD according to the levels of brain-derived neurotrophic factor (BDNF), inflammatory cytokines, and oxidative stress substances that exacerbate neuronal damage. Few articles have been published on this theme. They show that patients with BPD have a lower level of BDNF and a higher level of tumor necrosis factor (TNF)-α and interleukin (IL)-6 in peripheral blood, associated with increased plasma levels of oxidative stress markers, such as malondialdehyde and 8-hydroxy-2-deoxyguanosine. Therefore, more research on the topic is needed, mainly with a pre-clinical and clinical focus.


Full text: Available Index: LILACS (Americas) Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2023 Type: Article Affiliation country: Brazil / United kingdom Institution/Affiliation country: Kings College London/GB / Universidade Federal do Amapá/BR / Universidade Federal do Ceará/BR

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Full text: Available Index: LILACS (Americas) Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2023 Type: Article Affiliation country: Brazil / United kingdom Institution/Affiliation country: Kings College London/GB / Universidade Federal do Amapá/BR / Universidade Federal do Ceará/BR