Outcomes of endoscopic and open resection of sinonasal malignancies: a systematic review and meta-analysis
Braz. j. otorhinolaryngol. (Impr.)
;
88(supl.5): 19-31, Nov.-Dec. 2022. tab, graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1420904
ABSTRACT
Abstract Objective:
To compare the efficacy of endoscopic and open resection of sinonasal malignancies.Methods:
The search was performed using PubMed (1950-2020), Embase (1974-2020), the Cochrane library, and the website clinicaltrials.gov. The hazard ratio, HR, 95% confidence interval, CI, of the rates of overall survival and disease-free survival and the demographic characteristics of the included studies were extracted and analyzed. Pooled analysis was conducted with the studies' individual patient data, using log-rank test, Kaplan-Meier survival, and Cox regression analysis.Results:
Of 1939 articles retrieved, 23 articles were included. Overall, 1373 cases were incorporated into the final analysis, 653 (47.56%) of which underwent the surgery through an endoscopic approach, whereas 720 (52.44%) cases utilized the open approach. The overall survival was comparable between endoscopic and open resection (HR = 0.84 [95% CI 0.65-1.07], p = 0.16; random effects analysis). Pooled analysis with Cox regression revealed significant differences in overall survival (HR = 0.568 [95%CI0.380-0.849], p = 0.006) and disease-free survival (HR = 0.628 [95%CI0.424-0.929], p = 0.02) between endoscopic and open approaches.Conclusion:
The aggregated evidence suggests the survival outcome of endoscopic resection is comparable or greater than that of open resection of sinonasal malignancies.
Full text:
Available
Index:
LILACS (Americas)
Type of study:
Systematic reviews
Language:
English
Journal:
Braz. j. otorhinolaryngol. (Impr.)
Journal subject:
Otolaryngology
Year:
2022
Type:
Article
/
Project document
Affiliation country:
China
Institution/Affiliation country:
Central South University & Hunan Province/CN
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