Your browser doesn't support javascript.
loading
Effects of tobacco on the DNA of smokers and non-smokers affected by OSCC: systematic review and meta-analysis
SCHUCH, Lauren Frenzel; VIANA, Karolina Skarlet Silva; ARRUDA, José Alcides Almeida de; ABREU, Lucas Guimarães; AGUIAR, Maria Cássia Ferreira de; BERNARDES, Vanessa Fátima.
Affiliation
  • SCHUCH, Lauren Frenzel; Universidade Federal de Minas Gerais. School of Dentistry. Department of Oral Surgery and Pathology. Belo Horizonte. BR
  • VIANA, Karolina Skarlet Silva; Universidade Federal de Minas Gerais. School of Dentistry. Department of Oral Surgery and Pathology. Belo Horizonte. BR
  • ARRUDA, José Alcides Almeida de; Universidade Federal de Minas Gerais. School of Dentistry. Department of Oral Surgery and Pathology. Belo Horizonte. BR
  • ABREU, Lucas Guimarães; Universidade Federal de Minas Gerais. School of Dentistry. Department of Childs and Adolescents Oral Health. Belo Horizonte. BR
  • AGUIAR, Maria Cássia Ferreira de; Universidade Federal de Minas Gerais. School of Dentistry. Department of Oral Surgery and Pathology. Belo Horizonte. BR
  • BERNARDES, Vanessa Fátima; Universidade Federal de Minas Gerais. Biological Sciences Institute. Department of Pathology. Belo Horizonte. BR
Braz. oral res. (Online) ; 37: e008, 2023. tab, graf
Article in En | LILACS-Express | LILACS, BBO | ID: biblio-1420950
Responsible library: BR1.1
ABSTRACT
Abstract Scientific evidence about genetic and molecular changes in oral squamous cell carcinoma (OSCC) among smokers and non-smokers is inconclusive. This systematic review and meta-analysis assessed the effects of tobacco on the DNA of individuals with OSCC based on protein mutations. Electronic searches were conducted on PubMed, Ovid, Web of Science, and Scopus to identify observational studies published up to January/2022. The Joanna Briggs Institute tool was used for the critical appraisal of studies. The certainty of the evidence was evaluated. Twenty-three studies assessing 4,060 individuals (2,967 smokers vs. 1,093 non-smokers) were included in this review. Fifteen groups of proteins/genes were investigated. Analysis of the quality of articles revealed low risk of bias in most studies. The certainty of the evidence was very low. The meta-analysis confirmed no significant difference between smokers and non-smokers with respect to damage to GSTM1 (OR 0.60; 95%CI 0.30-1.18), GSTT1 (OR 1.18; 95%CI0.49-2.83), hydrolase proteins (Ku70 and Ku80) (OR 0.74; 95%CI 0.18-3.05), and transferase proteins (GSTM1, GSTT1, GSTM3) (OR 0.74; 95%CI 0.47-1.18). Most of the studies included showed that smokers are more likely to exhibit genetic instability. However, the meta-analysis revealed that smokers do not necessarily have more genetic alterations in the DNA than non-smokers.
Key words

Full text: 1 Index: LILACS Type of study: Observational_studies / Systematic_reviews Language: En Journal: Braz. oral res. (Online) Journal subject: ODONTOLOGIA Year: 2023 Type: Article / Project document

Full text: 1 Index: LILACS Type of study: Observational_studies / Systematic_reviews Language: En Journal: Braz. oral res. (Online) Journal subject: ODONTOLOGIA Year: 2023 Type: Article / Project document