Effects of tobacco on the DNA of smokers and non-smokers affected by OSCC: systematic review and meta-analysis
Braz. oral res. (Online)
; 37: e008, 2023. tab, graf
Article
in En
|
LILACS-Express
| LILACS, BBO
| ID: biblio-1420950
Responsible library:
BR1.1
ABSTRACT
Abstract Scientific evidence about genetic and molecular changes in oral squamous cell carcinoma (OSCC) among smokers and non-smokers is inconclusive. This systematic review and meta-analysis assessed the effects of tobacco on the DNA of individuals with OSCC based on protein mutations. Electronic searches were conducted on PubMed, Ovid, Web of Science, and Scopus to identify observational studies published up to January/2022. The Joanna Briggs Institute tool was used for the critical appraisal of studies. The certainty of the evidence was evaluated. Twenty-three studies assessing 4,060 individuals (2,967 smokers vs. 1,093 non-smokers) were included in this review. Fifteen groups of proteins/genes were investigated. Analysis of the quality of articles revealed low risk of bias in most studies. The certainty of the evidence was very low. The meta-analysis confirmed no significant difference between smokers and non-smokers with respect to damage to GSTM1 (OR 0.60; 95%CI 0.30-1.18), GSTT1 (OR 1.18; 95%CI0.49-2.83), hydrolase proteins (Ku70 and Ku80) (OR 0.74; 95%CI 0.18-3.05), and transferase proteins (GSTM1, GSTT1, GSTM3) (OR 0.74; 95%CI 0.47-1.18). Most of the studies included showed that smokers are more likely to exhibit genetic instability. However, the meta-analysis revealed that smokers do not necessarily have more genetic alterations in the DNA than non-smokers.
Full text:
1
Index:
LILACS
Type of study:
Observational_studies
/
Systematic_reviews
Language:
En
Journal:
Braz. oral res. (Online)
Journal subject:
ODONTOLOGIA
Year:
2023
Type:
Article
/
Project document