Your browser doesn't support javascript.
loading
The association of diabetes, subclinical hypothyroidism and carotid intima-media thickness: results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brazil)
Spilack, Aída de Melo; Goulart, Alessandra C.; Almeida-Pititto, Bianca de; Janovsky, Carolina Castro Porto Silva; Lotufo, Paulo A.; Santos, Itamar de Souza; Benseñor, Isabela M..
  • Spilack, Aída de Melo; Universidade de São Paulo. School of Medicine. Post-Graduate Student. São Paulo. BR
  • Goulart, Alessandra C.; Universidade de São Paulo. Hospital Universitário. Centro de Pesquisa Clínica e Epidemiológica. São Paulo. BR
  • Almeida-Pititto, Bianca de; Universidade de São Paulo. Faculdade de Saúde Pública. Departamento de Epidemiologia. São Paulo. BR
  • Janovsky, Carolina Castro Porto Silva; Universidade de São Paulo. Hospital Universitário. Centro de Pesquisa Clínica e Epidemiológica. São Paulo. BR
  • Lotufo, Paulo A.; Universidade de São Paulo. Hospital Universitário. Centro de Pesquisa Clínica e Epidemiológica. São Paulo. BR
  • Santos, Itamar de Souza; Universidade de São Paulo. Hospital Universitário. Centro de Pesquisa Clínica e Epidemiológica. São Paulo. BR
  • Benseñor, Isabela M.; Universidade de São Paulo. Hospital Universitário. Centro de Pesquisa Clínica e Epidemiológica. São Paulo. BR
Clinics ; 78: 100154, 2023. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1421265
ABSTRACT
Abstract

Introduction:

The association of diabetes with subclinical thyroid diseases may increase the risk of cardiovascular diseases. We analyzed the association of subclinical hypothyroidism, diabetes, and both diseases with carotid Intima-Media Thickness (cIMT) as a surrogate maker for early cardiovascular disease in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

Methods:

Cross-sectional analysis with data from the 3rd visit (2017‒2019). Linear regression models were used to evaluate the association of subclinical hypothyroidism, diabetes and of both diseases with a cIMT presented as Beta (95% Confidence Interval - 95% CI) without adjustment, with adjustment for sociodemographic variables (Model 1) and multivariable adjustment (Model 1 more cardiovascular risk factors). We also used logistic regression models to analyze the Odds Ratio (OR) and 95% CI for the association of both diseases using cIMT > P75%.

Results:

After the exclusion of patients with previous cardiovascular disease, 5,077 participants with no diseases, 1578 with diabetes, 662 with subclinical hypothyroidism, and 234 with both diseases were included in the analysis. Linear regression models showed an association of cIMT with only diabetes (β = 0.019; 95% CI 0.012 to 0.027; p < 0.0001) and subclinical hypothyroidism more diabetes (β = 0.03; 95% CI 0.010‒0.047, p < 0.0001). The logistic regression model reported an association between diabetes and CIMT higher than P75% (OR = 1.49, 95% CI 1.30‒1.71). No interaction between diabetes and subclinical hypothyroidism was detected using cIMT respectively as a continuous (p = 0.29) or as a categorical variable (p = 0.92).

Discussion:

Diabetes was associated with higher cIMT values. However, no additive effect of subclinical hypothyroidism associated with diabetes over cIMT was detected.


Full text: Available Index: LILACS (Americas) Type of study: Observational study / Prognostic study / Risk factors Country/Region as subject: South America / Brazil Language: English Journal: Clinics Journal subject: Medicine Year: 2023 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Type of study: Observational study / Prognostic study / Risk factors Country/Region as subject: South America / Brazil Language: English Journal: Clinics Journal subject: Medicine Year: 2023 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR