Immunophenotypic characterization of acute leukemias in Bahia, Brazil
Einstein (Säo Paulo)
;
21: eAO0117, 2023. tab, graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1421375
ABSTRACT
ABSTRACT Objective To characterize the immunophenotypic profile of acute leukemias in the population of the state of Bahia, Brazil. Methods This is a descriptive, retrospective study. From 2014 to 2018, 796 new cases of acute leukemia were evaluated. The data were obtained from analysis of reports and records of tests performed by flow cytometry immunophenotyping. All individuals of all age groups diagnosed as acute lymphoblastic leukemia or acute myeloid leukemia were included in the study. Demographic variables and expression of leukemia antigens were evaluated. Results Most cases were diagnosed as acute myeloid leukemia and 42.7% as acute lymphoblastic leukemia. Significant differences were found in expression of markers in acute leukemias when age groups were compared, as well as in demographic characteristics. B-cell acute lymphoblastic leukemia was more prevalent than cases of T-cell origin. Assessing the aberrant markers in acute myeloid leukemias, the non-acute promyelocytic leukemia group presented expression of CD7 and CD56 as the most frequent ones. In B-cell acute lymphoblastic leukemia, the most frequent aberrant markers were CD66c, CD13 and CD33. Conclusion Significant differences were found as to several antigens when comparing adults and children, and these findings may contribute to future studies correlating the phenotypic profile to genetic characteristics and therapeutic response, including specific antigen therapies, which may be better targeted.
Full text:
Available
Index:
LILACS (Americas)
Type of study:
Observational study
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Einstein (Säo Paulo)
Journal subject:
Medicine
Year:
2023
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal da Bahia/BR
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