Your browser doesn't support javascript.
loading
Actn3 gene polymorphism and factors associated with functional performance in elderly women assisted in primary health care / Polimorfismo do gene actn3 e os fatores associados ao desempenho funcional de idosas atendidas na atenção primária em saúde
Machado, Leandro César Teixeira; Leite, Mateus Medeiros; Stival, Marina Morato; Barbalho, Yuri Gustavo de Sousa; Lima, Filipe Dinato de; Lima, Luciano Ramos de; Silva, Alessandro de Oliveira; Silva, Izabel Cristina Rodrigues da; Funghetto, Silvana Schwerz.
  • Machado, Leandro César Teixeira; University of Brasília. Brasília. BR
  • Leite, Mateus Medeiros; University of Brasília. Brasília. BR
  • Stival, Marina Morato; University of Brasília. Brasília. BR
  • Barbalho, Yuri Gustavo de Sousa; University of Brasília. Brasília. BR
  • Lima, Filipe Dinato de; University Center of Brasília. Brasília. BR
  • Lima, Luciano Ramos de; University of Brasília. Brasília. BR
  • Silva, Alessandro de Oliveira; University Center of Brasília. Brasília. BR
  • Silva, Izabel Cristina Rodrigues da; University of Brasília. Brasília. BR
  • Funghetto, Silvana Schwerz; University of Brasília. Brasília. BR
J. Phys. Educ. (Maringá) ; 33: e3351, 2022. tab, graf
Article in English | LILACS | ID: biblio-1421868
ABSTRACT
ABSTRACT

Objective:

To analyze potential influences of the R/X genetic polymorphism of the ACTN3 gene, as well as of anthropometric and metabolic characteristics on the functional performance of elderly women assisted in primary health care.

Method:

One hundred and forty-one elderly women were assessed in terms of anthropometric, metabolic and functional aspects, in addition to clinical, cognitive and demographic characteristics. Allele and genotype frequencies of ACTN3 gene polymorphism were determined.

Results:

141 elderly women (68.30 ± 6.18 years) were evaluated. No significant differences (p > 0.05) were observed between the RR and RX/XX genotypes in the elderly women's functional performance, anthropometric or metabolic characteristics. The TUG test completion time showed positive correlations with age, body mass index, waist circumference, and fat percentage (s = 0.315; p < 0.001; s = 0.238; p = 0.005; s = 0.174; p = 0.039; s = 0.207; p = 0.014), respectively. Negative correlations were found between the TUG test with absolute handgrip strength (s = - 0.314; p < 0.001) and relative handgrip strength (s = - 0.380; p < 0.001).

Conclusion:

In our study, there were no influences from ACTN3 gene polymorphisms on the functional performance of the elderly women, which is influenced by other factors.
RESUMO
RESUMO

Objetivo:

analisar as potenciais influências do polimorfismo genético R/X do gene ACTN3 e das características antropométricas e metabólicas no desempenho funcional de mulheres idosas atendidas na atenção primária em saúde.

Método:

Cento e quarenta e uma idosas foram avaliadas em relação as características antropométricas, metabólicas, funcionais, aspectos clínicos, cognitivos e demográficos. Foram determinadas as frequências de alelos e genótipos do polimorfismo do gene ACTN3.

Resultados:

141 idosas (68,30 ± 6,18 anos) foram avaliadas. Não foram observadas diferenças significativas (p > 0,05) entre os genótipos RR e RX/XX no desempenho funcional, características antropométricas ou metabólicas das idosas. O tempo de realização do TUG apresentou correlações positivas com idade, índice de massa corporal, circunferência da cintura e percentual de gordura (s = 0,315; p < 0,001; s = 0,238; p = 0,005; s = 0,174; p = 0,039; s = 0,207; p = 0,014) respectivamente. Correlações negativas foram observadas entre o TUG com força de preensão manual absoluta (s = - 0,314; p < 0,001) e relativa (s = - 0,380; p < 0,001).

Conclusão:

Em nosso estudo, não foram observadas influências dos polimorfismos do gene ACTN3 no desempenho funcional das idosas, sendo este, influenciado por outros fatores.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Primary Health Care / Genetic Variation / Women / Aged Type of study: Practice guideline / Risk factors Limits: Aged / Female / Humans Language: English Journal: J. Phys. Educ. (Maringá) Journal subject: Medicina Esportiva Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: University Center of Brasília/BR / University of Brasília/BR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Primary Health Care / Genetic Variation / Women / Aged Type of study: Practice guideline / Risk factors Limits: Aged / Female / Humans Language: English Journal: J. Phys. Educ. (Maringá) Journal subject: Medicina Esportiva Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: University Center of Brasília/BR / University of Brasília/BR