Predictors of extubation outcomes among extremely and very preterm infants: a retrospective cohort study
J. pediatr. (Rio J.)
;
98(6): 648-654, Nov.-Dec. 2022. tab, graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1422002
ABSTRACT
Abstract Objective:
To explore the clinical or sociodemographic predictors for both successful and failed extubation among Chinese extremely and very preterm infantsMethods:
A retrospective cohort study was carried out among extremely and very preterm infants born at less than 32 weeks of gestational age (GA).Results:
Compared with the infants who experienced extubation failure, the successful infants had higher birth weight (OR 0.997; CI 0.996-0.998), higher GA (OR 0.582; 95% CI 0.499-0.678), a caesarean section delivery (OR 0.598; 95% CI 0.380-0.939), a higher five-minute Apgar score (OR 0.501; 95% CI 0.257-0.977), and a higher pH prior to extubation (OR 0.008; 95% CI 0.001-0.058). Failed extubation was associated with older mothers (OR 1.055; 95% CI 1.013-1.099), infants intubated in the delivery room (OR 2.820; 95% CI 1.742-4.563), a higher fraction of inspired oxygen (FiO2) prior to extubation (OR 5.246; 95% CI 2.540-10.835), higher partial pressure of carbon dioxide (PCO2) prior to extubation (OR 7.820; 95% CI 3.725-16.420), and higher amounts of lactic acid (OR 1.478;95% CI1.063-2.056).Conclusions:
Higher GA, higher pre-extubation pH, lower pre-extubation FiO2 and PCO, and lower age at extubation are significant predictors of successful extubation among extremely and very preterm infants.
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Index:
LILACS (Americas)
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Language:
English
Journal:
J. pediatr. (Rio J.)
Journal subject:
Pediatrics
Year:
2022
Type:
Article
/
Project document
Affiliation country:
China
Institution/Affiliation country:
Guangzhou Medical University/CN
/
The Hong Kong Polytechnic University/CN
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