Growth phenotypes of very low birth weight infants for prediction of neonatal outcomes from a Brazilian cohort: comparison with INTERGROWTH
J. pediatr. (Rio J.)
;
99(1): 86-93, Jan.-Feb. 2023. tab
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1422027
ABSTRACT
Abstract Objective:
To assess the predictive value of selected growth phenotypes for neonatal morbidity and mortality in preterm infants < 30 weeks and to compare them with INTERGROWTH-21st (IG21).Methods:
Retrospective analysis of data from the Brazilian Neonatal Research Network (BNRN) database for very low birth weight (VLBW) at 20 public tertiary-care university hospitals.Outcome:
the composite neonatal morbidity and mortality (CNMM) consisted of in-hospital death, oxygen use at 36 weeks, intraventricular hemorrhage grade 3 or 4, and Bell stage 2 or 3 necrotizing enterocolitis. Selected growth phenotypes small-for-gestational-age (SGA) defined as being < 3rd (SGA3) or 10th (SGA10) percentiles of BW, and large-for-gestational-age (LGA) as being > 97th percentile of BW. Stunting as being < 3rd percentile of the length and wasting as being < 3rd percentile of BMI. Single and multiple log-binomial regression models were fitted to estimate the relative risks of CNMM, comparing them to IG21.Results:
4,072 infants were included. The adjusted relative risks of CNMM associated with selected growth phenotypes were (BNRN/IG21) 1.45 (0.92-2.31)/1.60 (1.27-2.02) for SGA; 0.90 (0.55-1.47)/1.05 (0.55-1.99) for LGA; 1.65 (1.08-2.51)/1.58 (1.28-1.96) for stunting; and 1.48 (1.02-2.17) for wasting. Agreement between the two references was variable. The growth phenotypes had good specificity (>95%) and positive predictive value (70-90%), with poor sensitivity and low negative predictive value.Conclusion:
The BNRN phenotypes at birth differed markedly from the IG21 standard and showed poor accuracy in predicting adverse neonatal outcomes.
Full text:
Available
Index:
LILACS (Americas)
Type of study:
Prognostic study
/
Risk factors
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
J. pediatr. (Rio J.)
Journal subject:
Pediatrics
Year:
2023
Type:
Article
Affiliation country:
Argentina
/
Brazil
Institution/Affiliation country:
Fundação Oswaldo Cruz/BR
/
Hospital Estadual Sumaré/BR
/
Hospital Estadual de Diadema/BR
/
Hospital Geral de Pirajussara/BR
/
Maternidade Escola Hilda Brandão/BR
/
Pontifícia Universidade Católica do Rio Grande do Sul/BR
/
Sociedad Argentina de Pediatria/AR
/
Universidade Estadual Paulista/BR
/
Universidade Estadual de Campinas/BR
/
Universidade Estadual de Londrina/BR
Similar
MEDLINE
...
LILACS
LIS