Potentially inappropriate medications based on TIME criteria and risk of in-hospital mortality in COVID-19 patients
Rev. Assoc. Med. Bras. (1992, Impr.)
;
68(12): 1730-1736, 2022. tab
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1422569
ABSTRACT
SUMMARY OBJECTIVE:
This study aimed to evaluate the relationship between hospital admission potentially inappropriate medications use (PIM) and in-hospital mortality of COVID-19, considering other possible factors related to mortality.METHODS:
The Turkish inappropriate medication use in the elderly (TIME) criteria were used to define PIM. The primary outcome of this study was in-hospital mortality.RESULTS:
We included 201 older adults (mean age 73.1±9.4, 48.9% females). The in-hospital mortality rate and prevalence of PIM were 18.9% (n=38) and 96% (n=193), respectively. The most common PIM according to TIME to START was insufficient vitamin D and/or calcium intake per day. Proton-pump inhibitor use for multiple drug indications was the most prevalent PIM based on TIME to STOP findings. Mortality was related to PIM in univariate analysis (p=0.005) but not in multivariate analysis (p=0.599). Older age (hazards ratio (HR) 1.08; 95% confidence interval (CI) 1.02-1.13; p=0.005) and higher Nutritional Risk Screening 2002 (NRS-2002) scores were correlated with in-hospital mortality (HR 1.29; 95%CI 1.00-1.65; p=0.042).CONCLUSION:
Mortality was not associated with PIM. Older age and malnutrition were related to in-hospital mortality in COVID-19.
Full text:
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Index:
LILACS (Americas)
Type of study:
Etiology study
/
Risk factors
Language:
English
Journal:
Rev. Assoc. Med. Bras. (1992, Impr.)
Journal subject:
EducaÆo em Sa£de
/
GestÆo do Conhecimento para a Pesquisa em Sa£de
/
Medicine
Year:
2022
Type:
Article
Affiliation country:
Turkey
Institution/Affiliation country:
Istanbul University, Faculty of Medicine/TR
/
Marmara University, Faculty of Medicine/TR
/
University of Medical Sciences, Şişli Hamidiye Etfal Training and Research Hospital/TR
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