Your browser doesn't support javascript.
loading
Fetal thymus in growth-restricted fetuses due to placental insufficiency
Takeno, Marisa Akemi; Nomura, Roseli Mieko Yamamoto.
  • Takeno, Marisa Akemi; Universidade de São Paulo. Faculty of Medicine. Department of Obstetrics and Gynecology. São Paulo. BR
  • Nomura, Roseli Mieko Yamamoto; Universidade de São Paulo. Faculty of Medicine. Department of Obstetrics and Gynecology. São Paulo. BR
Rev. Assoc. Med. Bras. (1992, Impr.) ; 69(1): 136-141, Jan. 2023. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1422592
ABSTRACT
SUMMARY

OBJECTIVE:

The aim of this study was to assess fetal thymus size by ultrasound in growth-restricted fetuses due to placental insufficiency and compare to high-risk and low-risk pregnancy fetuses with normal placental function.

METHODS:

This is a nested case-control study of pregnant women followed up at a university hospital (July 2012 to July 2013). In all, 30 pregnant women presenting small fetuses for gestational age (estimated fetal weight <p10) due to placental insufficiency (umbilical artery Doppler >p95) were compared to 30 high-risk and 30 low-risk pregnancies presenting normal Doppler indices. The thymus transverse diameter and perimeter were converted into zeta score according to the normal values for gestational age. Head circumference and femur length were used to calculate ratios.

RESULTS:

Fetal thymus were significantly lower in pregnancies with placental insufficiency when compared to high-risk and low-risk pregnancies presenting, respectively, transverse diameter zeta score (-0.69±0.83 vs. 0.49±1.13 vs. 0.83±0.85, p<0.001) and P zeta score (-0.73±0.68 vs. 0.45±0.96 vs. 0.26±0.89, p<0.001). There was also a significant difference (p<0.05) in the ratios among the groups pregnancies with placental insufficiency (TD/HC=0.10, P/FL=1.32, and P/HC=0.26), high-risk pregnancies (TD/HC=0.11, P/FL=1.40, and P/HC=0.30), and control group (DT/HC=0.11, P/FL=1.45, and P/HC=0.31).

CONCLUSION:

Fetal thymus size is reduced in growth-restricted fetuses due to placental insufficiency, suggesting fetal response as a consequence of the adverse environment.


Full text: Available Index: LILACS (Americas) Type of study: Observational study / Risk factors Language: English Journal: Rev. Assoc. Med. Bras. (1992, Impr.) Journal subject: Educa‡Æo em Sa£de / GestÆo do Conhecimento para a Pesquisa em Sa£de / Medicine Year: 2023 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Type of study: Observational study / Risk factors Language: English Journal: Rev. Assoc. Med. Bras. (1992, Impr.) Journal subject: Educa‡Æo em Sa£de / GestÆo do Conhecimento para a Pesquisa em Sa£de / Medicine Year: 2023 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR