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Effect of dexmedetomidine on tourniquet-induced skeletal muscle injury
Cheng, Wenjie; Wu, Zhe; Zhang, Jizheng; Ren, Wanlu.
  • Cheng, Wenjie; Tianjin Hospital. Department of Anesthesiology. Tianjin. CN
  • Wu, Zhe; Tianjin Hospital. Department of Anesthesiology. Tianjin. CN
  • Zhang, Jizheng; Tianjin Hospital. Department of Anesthesiology. Tianjin. CN
  • Ren, Wanlu; Tianjin Hospital. Department of Anesthesiology. Tianjin. CN
Rev. Assoc. Med. Bras. (1992, Impr.) ; 69(2): 228-232, Feb. 2023. graf
Article in English | LILACS-Express | LILACS | ID: biblio-1422623
ABSTRACT
SUMMARY

OBJECTIVE:

The aim of this study was to investigate whether dexmedetomidine could reduce tourniquet-induced skeletal muscle injury.

METHODS:

C57BL6 male mice were randomly assigned to sham, ischemia/reperfusion, and dexmedetomidine groups. Mice in the ischemia/reperfusion and dexmedetomidine groups received normal saline solution and dexmedetomidine intraperitoneally, respectively. The sham group underwent the same procedure as the ischemia/reperfusion group, with the exception of tourniquet application. Subsequently, the ultrastructure of the gastrocnemius muscle was observed, and its contractile force was examined. In addition, Toll-like receptor 4 and nuclear factor-κB expression within muscles was detected by Western blot.

RESULTS:

Dexmedetomidine alleviated myocyte damage and increased the contractility of skeletal muscles. Moreover, dexmedetomidine significantly inhibited the expression of Toll-like receptor 4/nuclear factor-κB in the gastrocnemius muscle.

CONCLUSION:

Taken together, these results demonstrate that dexmedetomidine administration attenuated tourniquet-induced structural and functional impairment of the skeletal muscle, partly through inactivation of the Toll-like receptor 4/nuclear factor-κB pathway.


Full text: Available Index: LILACS (Americas) Language: English Journal: Rev. Assoc. Med. Bras. (1992, Impr.) Journal subject: Educa‡Æo em Sa£de / GestÆo do Conhecimento para a Pesquisa em Sa£de / Medicine Year: 2023 Type: Article Affiliation country: China Institution/Affiliation country: Tianjin Hospital/CN

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Full text: Available Index: LILACS (Americas) Language: English Journal: Rev. Assoc. Med. Bras. (1992, Impr.) Journal subject: Educa‡Æo em Sa£de / GestÆo do Conhecimento para a Pesquisa em Sa£de / Medicine Year: 2023 Type: Article Affiliation country: China Institution/Affiliation country: Tianjin Hospital/CN