Your browser doesn't support javascript.
loading
Experimental carcinogenesis with 7, 12-dimethylbenz(a)anthrazene (DMBA) and its inhibition with isothi-ocyanates / Carcinogénesis experimental con 7, 12-dimetilbenzantraceno (DMBA) y su inhibición con isitiocianatos
Morales-Herrero, María; Ortega-Medina, Isicio.
  • Morales-Herrero, María; Universidad de Sevilla. Facultad de Medicina. Sevilla. ES
  • Ortega-Medina, Isicio; Universidad de Sevilla. Facultad de Medicina. Sevilla. ES
J. oral res. (Impresa) ; 11(4): 1-13, jul. 21, 2022. tab
Article in English | LILACS | ID: biblio-1427176
ABSTRACT

Introduction:

DMBA is a chemical carcinogen that induces carcinomas within a few weeks of its application. We developed an experimental model of carcinogenesis induced by DMBA dissolved in 0,5% paraffin oil (DMBA-PO), verifying the inhibitory effect of the carcinogenicity of phenyl isothiocyanate (PhITC), phenethyl (PhnITC) and benzyl isothiocyanate (BITC). Material and

Methods:

For this, 88 hamsters were distributed into three groups one exposed to DMBA-PO (Group 1, n=12), three subgroups (n=12) exposed to PhITC, PhnITC, BITC and DMBA-PO (Group 2, n=36) and four control subgroups (n=10) that were not exposed to the carcinogen in which PO (paraffin oil) and isothiocyanates were applied (Group 3, n=40).

Results:

The experiment had a duration of 20 weeks, at the end of which the inhibitory effect was established by comparing the lesions developed in the groups that received isothiocyanates with the group that was only treated with DMBA-PO. The carcinogenic effect of DMBA-PO is 100% (35 carcinomas) and the inhibitory effect was 0, whereas in the presence of isothiocyanates the carcinogenic effect decreases, with an inhibitory effect of 86% for BITC (5 carcinomas) and 74% for PhITC (9 carcinomas).

Conclusion:

The inhibitory effect for PhnITC is 80% in relation to invasive OSCC (1 carcinoma).
RESUMEN

Introducción:

El DMBA es un carcinógeno químico que induce carcinomas a las pocas semanas de su aplicación. Desarrollamos un modelo experimental de carcinogénesis inducida por DMBA disuelto en aceite de parafina al 0,5% (DMBA-Ap) comprobando el efecto inhibidor de la carcinogénesis de los isotiocianatos fenil (PhITC), fenetil (PhnITC) y bencil isotiocianato (BITC). Material y

Métodos:

Para ello, se distribuyeron 88 hámsteres en 3 grupos uno expuesto al DMBA-Ap (Grupo 1, n=12), tres subgrupos (n=12) expuestos a PhITC, PhnITC, BITC y DMBA-Ap (Grupo 2, n=36) y cuatro subgrupos controles (n=10), no expuestos al carcinógeno en el que se aplicaron Ap e isotiocianatos (Grupo 3, n=40).

Resultados:

El experimento tuvo una duración de 20 semanas, al final de la cual se establece de forma comparativa el efecto inhibidor comparando las lesiones desarrolladas en los grupos que recibieron isotiocianatos con respecto al grupo tratado sólo con DMBA-Ap. El efecto carcinógeno del DMBA-Ap es del 100% (35 carcinomas) y el efecto inhibidor 0, mientras que en presencia de isotiocianatos el efecto carcinógeno disminuye, con un efecto inhibidor del 86% para BITC (5 carcinomas) y del 74% para el PhITC (9 carcinomas).

Conclusión:

El efecto inhibidor del PhnITC es del 80% en relación con el COCE invasivo (1 carcinoma).
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Anticarcinogenic Agents / 9,10-Dimethyl-1,2-benzanthracene Limits: Animals Language: English Journal: J. oral res. (Impresa) Journal subject: Dentistry Year: 2022 Type: Article Affiliation country: Spain Institution/Affiliation country: Universidad de Sevilla/ES

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Anticarcinogenic Agents / 9,10-Dimethyl-1,2-benzanthracene Limits: Animals Language: English Journal: J. oral res. (Impresa) Journal subject: Dentistry Year: 2022 Type: Article Affiliation country: Spain Institution/Affiliation country: Universidad de Sevilla/ES