Histopathological examination of the protective effect of intense exercise in apoptotic germ cell damage due to diabetes
Acta cir. bras
;
38: e381423, 2023. tab, graf, ilus
Article
in English
| LILACS, VETINDEX
| ID: biblio-1429537
ABSTRACT
Purpose:
The aim of this study was to determine the protective and antioxidative effects of intensive exercise on streptozotocin (STZ)-induced testicular damage, apoptotic spermatognial cells death, and oxidative stress.Methods:
36 male Sprague Dawley rats were divided into three groups control, diabetes, and diabetes+intensive exercise (IE) groups. Testicular tissues were examined histopathologically and antioxidant enzymes, including catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and malondialdehyde (MDA) activity, as well as serum testosterone level, were measured.Results:
Seminiferous tubules and germ cells were found to be better in the testis tissue of the intense exercise group than in the diabetes group. Diabetes suppressed antioxidant enzymes CAT, SOD, GPx and testosterone levels were significantly decreased, and increased MDA level in the diabetic group compared to diabetes+IE group (p < 0.001). Following four weeks of treatment, intensive exercise improved the antioxidant defense, significantly decreased MDA activity, and increased testosterone levels in testicular tissue in the diabetic group compared to diabetes+IE group (p < 0.01).Conclusion:
STZ-induced diabetes causes damage to the testis tissue. In order to prevent these damages, exercise practice has become very popular nowadays. In present study, our intensive exercise protocol, histological, and biochemical analysis of the effect of diabetes on the testicular tissues is shown.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Spermatozoa
/
Exercise
/
Apoptosis
/
Oxidative Stress
/
Diabetes Mellitus, Experimental
/
Antioxidants
Type of study:
Practice guideline
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Year:
2023
Type:
Article
Institution/Affiliation country:
Antalya Research and Education Hospital/TR
/
Atatürk University/TR
/
Diyarbakir Memorial Hospital/TR
/
Eyyübiye Education and Research Hospital/TR
/
Private Medical Practice/TR
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