The triglyceride-glucose index as an indicator of insulin resistance and cardiometabolic risk in Brazilian adolescents
Arch. endocrinol. metab. (Online)
;
67(2): 153-161, 2023. tab
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1429732
ABSTRACT
ABSTRACT Objective:
To set cutoff points for the triglyceride and glucose index (TyG) as a marker of insulin resistance (IR) for the pediatric population. Subjects andmethods:
This was a cross-sectional study with schoolchildren population-based data using data of 377 schoolchildren age 10 to 17 years of both sexes. We studied metabolic variables associated with IR indicators, such as fasting insulin and blood glucose, to calculate the homeostatic model assessment (HOMA-IR), and we studied triglycerides (TG) to determine the TyG index. We obtained TyG cutoff values for IR using the receiver operation characteristic (ROC), with definitions of sensitivity (Sen), specificity (Spe), and area under the ROC curve (AUC), with the HOMA-IR as reference.Results:
The cutoff points of the TyG index for IR in adolescents are 7.94 for both sexes, 7.91 for boys, and 7.94 for girls, indicating moderate discriminatory power. When we also considered anthropometric variables of excess weight [TyG-BMI (body mass index)] and visceral fat [TyG-WC (waist circumference)], these indexes reached AUC values higher than 0.72, enhancing their potential use for a good diagnosis.Conclusion:
TyG has proven to be a useful instrument for identifying IR in adolescent health screening, with high discrimination capacity when added to anthropometric variables, making it a feasible and inexpensive option.
Full text:
Available
Index:
LILACS (Americas)
Type of study:
Etiology study
/
Observational study
/
Prognostic study
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Risk factors
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Arch. endocrinol. metab. (Online)
Journal subject:
Endocrinology
/
Metabolism
Year:
2023
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de São Carlos/BR
/
Universidade Federal do Rio Grande do Sul/BR
/
Universidade de Santa Cruz do Sul/BR
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