A retrospective analysis to estimate trough concentrations of teicoplanin in patients with suspected or documented Gram-positive infections
Braz. J. Pharm. Sci. (Online)
;
59: e21077, 2023. tab, graf
Article
in English
| LILACS
| ID: biblio-1429974
ABSTRACT
Abstract Teicoplanin is a glycopeptide antibiotic commonly used to treat Gram-positive bacterial infections in the clinic. The aim of this study was to provide a therapeutic reference for the clinical application and dosage regimen adjustment of teicoplanin by identifying factors associated with its plasma trough concentration (Ctrough). A retrospective study was performed on patients with suspected or documented Gram-positive infections who were hospitalized from November 2017 to January 2020 and treated with teicoplanin while undergoing routine therapeutic drug monitoring (TDM). A total of 112 Ctrough trough measurements were obtained from 72 patients were included in this study. SPSS software was used for correlation analysis and receiver operator characteristic curve (ROC) analysis. The Ctrough for teicoplanin showed statistically significant relationships (P<0.05) with PLT, Scr, CLcr, eGFR, BUN and Cys-C. ROC curve analysis revealed that CLcr and eGFR were more sensitive and specific for Ctrough compared to the other factors. These findings should be considered in the clinical application of teicoplanin and for its dosage adjustment.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Patients
/
Gram-Positive Bacterial Infections
/
Teicoplanin
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Braz. J. Pharm. Sci. (Online)
Journal subject:
Farmacologia
/
Teraputica
/
Toxicologia
Year:
2023
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Shenyang Research Institute of Chemical Industry/CN
/
the First Hospital of China Medical University/CN
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