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Osteometabolic profile and bone mass in the transition phase: ethnic differences in Brazilians treated with somatropin during childhood
Kuba, Valesca M.; Castro, Antonia B.S.; Leone, Cláudio; Damiani, Durval.
  • Kuba, Valesca M.; Universidade de São Paulo (USP). Instituto da Criança. Unidade de Endocrinologia Pediátrica. São Paulo. BR
  • Castro, Antonia B.S.; Universidade de São Paulo (USP). Instituto da Criança. Unidade de Endocrinologia Pediátrica. São Paulo. BR
  • Leone, Cláudio; Universidade de São Paulo (USP). Escola de Saúde Pública. Departamento de Saúde Materno-Infantil. São Paulo. BR
  • Damiani, Durval; Universidade de São Paulo (USP). Instituto da Criança. Unidade de Endocrinologia Pediátrica. São Paulo. BR
J. pediatr. (Rio J.) ; 99(2): 168-173, Mar.-Apr. 2023. tab
Article in English | LILACS-Express | LILACS | ID: biblio-1430703
ABSTRACT
Abstract

Objective:

The main growth hormone action is to promote linear growth increasing protein synthesis stimulation and osteoblastic activity. Peak bone mass extends from adolescence to 30 years of age. Several factors may influence this acquisition and prevent fracture risk in adulthood, such as genetic potential, GH, ethnicity, and lifestyle factors. This study aims to compare bone mass and osteometabolic profile of white and Afro-descendant Brazilian adolescents in the transition phase, who were treated with human recombinant growth hormone in childhood.

Methods:

The authors selected 38 adolescents from the Transition Outpatient Clinic of the University of São Paulo. Lumbar spine and total body bone mineral density (BMD) and bone mineral content (BMC), serum calcium, 25-OH-vitamin D and bone markers were analyzed at the rhGH withdrawal.

Results:

The mean age was 16.8 ± 1.6 years. There were 21 Afro-descendant and 17 whites. Thirty-four percent of the sample presented vitamin D insufficiency, 66% inadequate calcium intake and 44.7% physical inactivity. The Afro-descendants showed a lower lumbar spine and total body Z scores than those of the whites (p = 0.04 and p = 0.03, respectively), as well as their mean body weight (p = 0.03). There were no differences in the remaining osteometabolic parameters.

Conclusion:

As most adolescents had vitamin D insufficiency, low calcium intake, and physical inactivity, calcium, and cholecalciferol supplementation and lifestyle changes should be encouraged. The Brazilian Afro-descendant may be a vulnerable group for low bone mass, requiring


Full text: Available Index: LILACS (Americas) Country/Region as subject: South America / Brazil Language: English Journal: J. pediatr. (Rio J.) Journal subject: Pediatrics Year: 2023 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo (USP)/BR

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Full text: Available Index: LILACS (Americas) Country/Region as subject: South America / Brazil Language: English Journal: J. pediatr. (Rio J.) Journal subject: Pediatrics Year: 2023 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo (USP)/BR