Nonalcoholic fatty liver disease in adolescents with phenylketonuria
J. pediatr. (Rio J.)
;
99(2): 174-180, Mar.-Apr. 2023. tab
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1430708
ABSTRACT
Abstract Objective:
This study aimed to investigate non-alcoholic fatty liver disease (NAFLD) occurrence and factors associated with the disease in phenylketonuria (PKU) patients undergoing exclusive dietary treatment.Method:
This cross-sectional study included 101 adolescents 10 to < 20 years of age with PKU, who were undergoing exclusive dietary treatment and monitored since early diagnosis at a single reference service. Anthropometric and biochemical assessments were performed and food intake was documented, and an ultrasound diagnosis of NAFLD was established. Data were evaluated using the Student's t-test for continuous variables, the chi-square for categorical variables, and logistic regression using the Wald chi-squared test; differences with p < 0.05 were considered to be statistically significant.Results:
NAFLD was detected in 26 (25.7%) teenagers. There was no difference in prevalence between the sexes or nutritional status. The final logistic regression model revealed low sensitivity (26.1%) and high specificity (94.7%). The specificity suggested a lower likelihood of NAFLD in older adolescents, in the presence of normal or high levels of alkaline phosphatase, lower carbohydrate intake, and adequate protein and lipid intake.Conclusions:
The prevalence of NAFLD in adolescents with PKU was higher than that found in healthy Brazilian adolescents and similar to that found in obese Brazilian children, suggesting a higher risk for NAFLD in patients with PKU treated exclusively by dietary modification.
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Index:
LILACS (Americas)
Type of study:
Observational study
/
Prognostic study
/
Risk factors
/
Screening study
Language:
English
Journal:
J. pediatr. (Rio J.)
Journal subject:
Pediatrics
Year:
2023
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Clínica CEU Diagnósticos/BR
/
Faculdade de Minas (FAMINAS-BH)/BR
/
Pontifícia Universidade Católica de Minas Gerais (PUC-Minas)/BR
/
Universidade Federal da Bahia (UFBA)/BR
/
Universidade Federal de Minas Gerais (UFMG)/BR
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