Autonomic dysfunction in COVID-19 patients receiving mechanical ventilation: A cross-sectional study
São Paulo med. j
;
141(6): e2022513, 2023. tab, graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1432469
ABSTRACT
ABSTRACT BACKGROUND:
Coronavirus disease 2019 (COVID-19) can damage cardiac tissue by increasing troponin levels and inducing arrhythmias, myocarditis, and acute coronary syndrome.OBJECTIVES:
To analyze the impact of COVID-19 on cardiac autonomic control in mechanically ventilated intensive care unit (ICU) patients. DESIGN ANDSETTING:
This cross-sectional analytical study of ICU patients of both sexes receiving mechanical ventilation was conducted in a tertiary hospital.METHODS:
Patients were divided into COVID-19-positive (COVID(+)) and COVID-19-negative (COVID(-)) groups. Clinical data were collected and heart rate variability (HRV) records obtained using a heart rate monitor.RESULTS:
The study sample comprised 82subjects:
36 (44%) in the COVID(-) group (58.3% female; median age, 64.5 years) and 46 (56%) in the COVID(+) group (39.1% females; median age, 57.5 years). The HRV indices were lower than the reference values. An intergroup comparison identified no statistically significant differences in the mean normal-to-normal (NN) interval, standard deviation of the NN interval, or root mean square of successive differences in NN intervals. The COVID(+) group had an increased low frequency (P = 0.05), reduced high frequency (P = 0.045), and increased low frequency/high frequency (LF/HF) ratio (P = 0.048). There was a weak positive correlation between LF/HF and length of stay in the COVID(+) group.CONCLUSION:
Patients who received mechanical ventilation had lower overall HRV indices. COVID(+) patients who received mechanical ventilation had lower vagal HRV components. These findings likely indicate clinical applicability, as autonomic control impairments are associated with a greater risk of cardiac death.
Full text:
Available
Index:
LILACS (Americas)
Type of study:
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
Language:
English
Journal:
São Paulo med. j
Journal subject:
Cirurgia Geral
/
Cincia
/
Ginecologia
/
Medicine
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Year:
2023
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Programa de Pós-Graduação em Reabilitação e Desempenho Funcional/BR
/
Universidade Ceuma/BR
/
Universidade Federal de Pernambuco/BR
/
Universidade de Pernambuco/BR
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