Incidence of blood culture-related sepsis in neonates and antibiotics sensitivity of implicated organisms in a secondary healthcare facility in Ghana
Ghana Med. J. (Online)
;
57(2): 134-140, 2023. figures, tables
Article
in English
| AIM
| ID: biblio-1436300
ABSTRACT
Objective:
We determined the incidence of blood culture-related sepsis, causative bacteria, and antibiotics sensitivity among newborn babies with suggestive signs of sepsis admitted at the Upper East Regional Hospital in Bolgatanga, Ghana.Design:
Prospective cross-sectional studySetting:
Newborn Care Unit of the Upper East Regional Hospital, BolgatangaParticipants:
Neonates admitted to the Newborn Care Unit from August 2019 to August 2020 with signs of sepsis Main outcomemeasures:
Organisms isolated from blood cultures and sensitivity of isolated organisms to antibiotics.Results:
The study included two hundred and seventy-six (276) patients. Laboratory confirmed sepsis was 13.4% (37/276). Early onset sepsis was 3.3% (9/276), while late-onset sepsis was 10.1% (28/276). The most common clinical signs associated with positive culture cases were temperature instability (35.5%), poor feeding (14.5%), neonatal jaundice (11.3%), vomiting (9.7%), and respiratory distress (8.1%). Staphylococcus aureus and Staphylococcus epidermidis were the most common bacterial isolates (46% and 32%, respectively). There was no relationship between independent variables and blood culture confirmed sepsis. Antibiotics to which isolates were most resistant included flucloxacillin 4/4, penicillin 14/15, ampicillin 16/18, and tetracycline 23/28. Bacterial isolates were most sensitive to amikacin 16/16, levofloxacin 5/5, erythromycin 8/8, cefazolin 7/8, and ciprofloxacin 18/24.Conclusion:
Late-onset sepsis is a common sepsis category, and the implicated microorganisms are resistant to commonly prescribed antibiotics.
Full text:
Available
Index:
AIM (Africa)
Limits:
Infant
/
Infant, Newborn
Language:
English
Journal:
Ghana Med. J. (Online)
Year:
2023
Type:
Article
Institution/Affiliation country:
2CK Tedam University for Technology and Applied Sciences, Navrongo, Upper East Region, Ghana/GH
/
Directorate of Family Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana/GH
/
Microbiology Laboratory. Upper East Regional Hospital, Bolgatanga, Ghana/GH
/
Newborn Care Unit, Upper East Regional Hospital, Bolgatanga, Ghana/GH
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