Prevalence of Donor-Associated Infections in Lung Transplant Recipients
Rev. am. med. respir
;
22(1): 41-50, mar. 2022. graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1441103
ABSTRACT
Abstract The infectious complication is the most common condition after a transplantation. There is a limited description regarding the preva lence of donor-associated infections (DAIs) in lung transplant (LTx) recipients. There are reports of DAIs in LTx recipients of 7.6%, with documented prophylactic failure of 5.6%. Objective: to estimate the frequency of donor-associated infections after lung transplantation and their outcome in terms of overall survival (OS). Methodology: an observational, descriptive study, carried out in a transplant center in Argentina between January 2018 and June 2020. The study included all the patients who underwent a transplantation within such period and those with defined/proven DAIs. Results: during the aforementioned period, 65 LTx were performed in 64 individuals (one patient underwent transplantation and subsequent retransplantation in the same study period). The median age was 39 (12-72) years. Cystic fibrosis was the main reason for transplantation (26.2%) In 61/65 cases (94%), germs were isolated from biological samples collected from the donor: 78.6% in the preservation liquid, 73.7% in donor secretions, 21.3% surgical samples, and 4.9% blood cultures. Donor-associated infections were identified in 2/61 cases (prevalence of 3.1%; 95% CI: 0.4-10.7%), with a median posttransplant OS of 12 months, and an OS of 98.4% (95% CI: 91.7-99.9%). Conclusion: the prevalence of DAIs in LTx recipients in the present series was 3.1%: higher than the figures documented for solid organ transplants in general (< 1%), but lower than the numbers found in the few published reports (7.6%).
Full text:
Available
Index:
LILACS (Americas)
Type of study:
Prevalence study
/
Risk factors
Language:
English
Journal:
Rev. am. med. respir
Journal subject:
Medicine
/
Pulmonary Disease (Specialty)
Year:
2022
Type:
Article
Affiliation country:
Argentina
Institution/Affiliation country:
Hospital Universitario Fundación Favaloro/AR
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