Correlation of fasting blood, salivary glucose and malondialdehyde in subjects with & without type 2 diabetes
Braz. j. oral sci
;
22: e239042, Jan.-Dec. 2023. ilus
Article
in English
| LILACS, BBO
| ID: biblio-1442837
ABSTRACT
Oxidative stress is identified as the common pathogenic factor that leads to insulin resistance in diabetics. Malondialdehyde is a product of lipid peroxidation. Aim:
The aim of this study was to determine the variation in the Salivary malondialdehyde (MDA) among subjects with and without T2DM in comparison to the fasting blood and Salivary glucose.Methods:
This study involved 29 healthy participants as Controls (group I) and 29 participants with Type 2 Diabetes Mellitus as Cases (group II). Salivary Glucose was analysed by glucose oxidase end-point assay. Thiobarbituric acid (TBA) assay method was considered for estimation of MDA in fasting saliva. Data was Statistically analysed using SPSS20. Parametric test was performed to analyse the data.Results:
The correlation calculated between FBG with FSG level was found to be highly significant. A positive correlation between MDA levels with FBG was found. The relationship between FBG and FSG (r = 0.7815, p < 0.05), FBG and MDA (r =0.3678, p < 0.05) and FSG and MDA (r = 0.2869, p < 0.05) were found to be positively significant.Conclusion:
Saliva as a unique body fluid can serve as a medium for biochemical analysis only in standard settings and with multiple measures to be used as a diagnostic tool in par with the gold standard serum. Salivary MDA levels can be considered as one of the oxidative stress markers in Type 2 Diabetic conditionSubject(s)
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Biomarkers
/
Oxidative Stress
/
Diabetes Mellitus, Type 2
/
Glucose Oxidase
/
Malondialdehyde
Type of study:
Prognostic study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Braz. j. oral sci
Journal subject:
Dentistry
Year:
2023
Type:
Article
Affiliation country:
India
Institution/Affiliation country:
J.J.M.Medical College/IN
/
JSS Academy of Higher Education and Research/IN
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