Evaluación renal y multiorgánica en el paciente con encefalopatía hipóxico-isquémica / Renal and multiorgan evaluation in infants with post-asphyxial hypoxic-ischaemic encephalopathy
Perinatol. reprod. hum
;
37(1): 3-10, ene.-mar. 2023. tab, graf
Article
in Spanish
|
LILACS-Express
| LILACS
| ID: biblio-1448780
RESUMEN
Resumen Introducción:
La encefalopatía hipóxico-isquémica (EHI) moderada-grave secundaria a asfixia perinatal puede afectar a cualquier órgano, empeorando el pronóstico.Objetivo:
Evaluar la afectación renal y multiorgánica de estos pacientes. Material ymétodo:
Se incluyó a recién nacidos > 35 semanas con EHI moderada-grave tratados con hipotermia activa entre 2010 y 2020. Se evaluó la creatinina en tres periodos 48-72 horas de vida, entre el 3.o y 7.o día de vida y del 7.o al 28.o día de vida.Resultados:
Se incluyeron 135 pacientes 112 con EHI moderada y 23 con EHI grave. Al comparar ambos grupos, se obtuvieron diferencias significativas a las 48-72 horas y entre 3.o-7.o día de vida. No hubo diferencias al comparar el método de hipotermia. Los pacientes con EHI grave presentaron mayor afectación hemodinámica, respiratoria y hepática.Conclusiones:
Neonatos con EHI grave presentan aumento de los niveles de creatinina sérica y mayor afectación multiorgánica respecto a aquellos con EHI moderada.ABSTRACT
Abstract Background:
Hypoxic-ischemic encephalopathy (HIE) secondary to perinatal asphyxia can affect any organ, worsening the prognosis.Objective:
To describe renal and multiorgan involvement in moderate-severe HIE. Material andmethod:
Newborns > 35 weeks diagnosed with moderate-severe HIE who required active hypothermia between 2010-2020 were included. To assess renal involvement, serum creatinine was measured in three different periods at 48-72 hours, between the 3rd and the 7th day, and from the 7th to the 28th day.Results:
A total of 135 patients were included, 112 (83%) with moderate and 23 (17%) with severe HIE. Significant differences were obtained when comparing median creatinine levels at 48-72 hours and between 3-7 days in both groups. There were no differences in creatinine according to the hypothermia method. Patients with severe HIE presented greater hemodynamic, respiratory, and hepatic involvement.Conclusions:
Neonates with severe HIE present increased serum creatinine levels and greater multi-organ involvement than those with moderate HIE.
Full text:
Available
Index:
LILACS (Americas)
Language:
Spanish
Journal:
Perinatol. reprod. hum
Journal subject:
Perinatology
/
REPRODUCAO
Year:
2023
Type:
Article
Affiliation country:
Canada
/
Spain
Institution/Affiliation country:
Hospital General Universitario Gregorio Marañón/ES
/
Hospital for Sick Children/CA
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