Accelerating Wound Healing of Traumatic Ulcer with Topical Application of Dental Pulp Mesenchymal Stem Cell Secretome and Robusta Green Coffee Bean Extract Combination in vivo
Pesqui. bras. odontopediatria clín. integr
;
23: e210116, 2023. tab, graf
Article
in English
| LILACS, BBO
| ID: biblio-1448803
ABSTRACT
ABSTRACT Objective:
To investigate the ability of a combination dental pulp mesenchymal stem cell secretome (DPMSCS), robusta green coffee bean extract (RGCBE), and Carboxymethylcellulose-Natrium (CMC-Na) in a Wistar rats model of traumatic ulcers. Material andMethods:
Twenty-eight young, male, healthy Wistar rats (Rattus norvegicus) were divided into seven groups randomly Group K0, group K1-3 (traumatic ulcer rats that received CMC-Na gel for three days), group K1-7 (traumatic ulcer rats that received CMC-Na gel for seven days), group K2-3 (traumatic ulcer rats that received RGCBE for three days), group K2-7 (traumatic ulcer rats that received RGCBE for seven days), group K3-3 (traumatic ulcer rats that received DPMSCS for three days), and group K3-7 (traumatic ulcer rats that received DPMSCS for seven days). An ulcer was made with an amalgam stopper on the right buccal mucosa of the rats. DPMSCS 50% gel was applied to the ulcer on the left buccal mucosa. The ulcer diameter was measured on day 3 and day 7.Results:
There was a significant difference in the diameter of the ulcer, the number of neutrophils, and fibroblasts in the treatment group compared to the control group on day 7.Conclusion:
A combination of DPMSCS and RGCBE 50% accelerates traumatic ulcer wound healing by lowering ulcer diameter, decreasing neutrophil counts, and increasing fibroblast proliferation in vivo.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Wound Healing
/
Plant Extracts
/
Dental Pulp
/
Mesenchymal Stem Cells
/
Fibroblasts
Limits:
Animals
Language:
English
Journal:
Pesqui. bras. odontopediatria clín. integr
Journal subject:
Dentistry
Year:
2023
Type:
Article
Affiliation country:
Indonesia
Institution/Affiliation country:
Jember University of Jember/ID
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