Does the use of oral contraceptives or hormone replacement therapy offer protection against the formation or rupture of intracranial aneurysms in women?: a systematic review and meta-analysis
Rev. Assoc. Med. Bras. (1992, Impr.)
;
69(supl.1): e2023S118, 2023. tab, graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1449125
ABSTRACT
SUMMARY OBJECTIVE:
The aim of this study was to carry out a systematic review of the literature with meta-analysis to evaluate the effect of using oral contraceptive and hormone replacement therapy as a protective factor in the formation of intracranial aneurysms and subarachnoid hemorrhage.METHODS:
This is a systematic review of the literature with meta-analysis, using PubMed and Embase as databases and the PRISMA method. Case-control and cohort studies published until December 2022 were included in this review.RESULTS:
Four studies were included in this review; three of which were eligible for meta-analysis. Regarding the use of oral contraceptive and the development of subarachnoid hemorrhage, there was a lower risk of aneurysm rupture with an odds ratio 0.65 (confidence interval 0.5-0.85). In the analysis of patients using hormone replacement therapy and developing subarachnoid hemorrhage, there was also a lower risk of aneurysm rupture with an OR 0.54 (CI 0.39-0.74). Only one article analyzed the formation of intracranial aneurysm and the use of hormone replacement therapy and oral contraceptive, and there was a protective effect with the use of these medications. oral contraceptive OR 2.1 (CI 1.2-3.8) and hormone replacement therapy OR 3.1 (CI 1.5-6.2).CONCLUSION:
The use of hormone replacement therapy and oral contraceptive has a protective effect in intracranial aneurysm rupture and formation.
Full text:
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Index:
LILACS (Americas)
Type of study:
Observational study
/
Risk factors
/
Systematic reviews
Language:
English
Journal:
Rev. Assoc. Med. Bras. (1992, Impr.)
Journal subject:
EducaÆo em Sa£de
/
GestÆo do Conhecimento para a Pesquisa em Sa£de
/
Medicine
Year:
2023
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
A Beneficência Portuguesa de São Paulo/BR
/
Hospital Sírio Libanês/BR
/
Sociedade de Neurocirurgia do Rio de Janeiro/BR
/
Universidade de São Paulo/BR
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