Association of PI3K/AKT/mTOR pathway autophagy-related gene polymorphisms with pulmonary tuberculosis susceptibility in a Chinese population
Rev. Soc. Bras. Med. Trop
;
56: e0104, 2023. tab, graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1449338
ABSTRACT
ABSTRACT Background:
Autophagy can inhibit the survival of intracellular microorganisms including Mycobacterium tuberculosis (Mtb), and the PI3K/AKT/mTOR pathway plays a crucial role. This study investigated the association between PI3K/AKT/mTOR pathway autophagy-related gene polymorphisms and pulmonary tuberculosis (PTB) susceptibility.Methods:
KEGG pathway and gene ontology (GO) databases were searched for genes belonging to the PI3K/AKT/mTOR and autophagy pathways. Thirty SNPs in nine genes were identified and tested for their associations with tuberculosis in 130 patients with PTB and 271 controls. We constructed genetic risk scores (GRSs) and divided the participants into 3 subgroups based on their GRSs0-5, 6-10, and 11-16.Results:
This analysis revealed that the AKT1 (rs12432802), RPTOR (rs11654508, rs12602885, rs2090204, rs2589144, and rs2672897), and TSC2 (rs2074969) polymorphisms were significantly associated with PTB risk. A decreasing trend was observed (P trend 0.020), in which a lower GRS was associated with a higher risk of PTB ([6-10] vs. [0-5] OR (95%CI) 0.590 (0.374-0.931); [11-16] vs. [0-5] OR (95%CI) 0.381 (0.160-0.906)).Conclusions:
Polymorphisms in AKT1, RPTOR, and TSC2 may influence susceptibility to PTB.
Full text:
Available
Index:
LILACS (Americas)
Type of study:
Prognostic study
/
Risk factors
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2023
Type:
Article
/
Project document
Affiliation country:
China
/
Venezuela
Institution/Affiliation country:
Harbin Medical University/CN
/
Laboratorio de Genética Molecular/VE
/
Shenzhen Nanshan Center for Chronic Disease Control/CN
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