The CXCL9/10/11-CXCR3 axis as a predictor of COVID-19 progression: a prospective, case-control study
Rev. Soc. Bras. Med. Trop
;
56: e0128, 2023. tab, graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1449352
ABSTRACT
ABSTRACT Background:
This study examined the relationship between levels of the chemokines CXCL9, CXCL10, CXCL11, and CXCR3 and mortality in patients with COVID-19..Methods:
A total of 71 patients hospitalized with COVID-19 and 35 health workers with no symptoms and negative SARS-CoV-2 PCR results were included in the study. CXCL9, CXCL10, CXCL11, and CXCR3 levels were measured in blood samples using enzyme-linked immunosorbent assays. Participants were divided into three groups healthy individuals, patients with mild to moderate pneumonia, and patients with severe pneumonia. Patients were also divided into sub-groups according to theoutcome:
dead and survived.Results:
Serum CXCL9, CXCL10, CXCL11, and CXCR3 levels were significantly higher in patients with severe COVID-19 than in those with non-severe COVID-19; were higher in both patient groups than in the control group; and were higher in patients who died than in those who survived. Lymphocyte counts, and fibrinogen and PaO2/FiO2 levels were significantly lower in patients with severe COVID-19 than in those with moderate disease. Patients with COVID-19 also had elevated neutrophil/lymphocyte ratios, neutrophil counts, and lactate dehydrogenase, C-reactive protein, D-dimer, and ferritin levels.Conclusions:
This study confirmed that CXCL9, CXCL10, CXCL11, and CXCR3 levels are associated with disease severity in patients with COVID-19. These laboratory parameters can help to estimate disease severity and predict outcomes, and are useful in clinical decision-making.
Full text:
Available
Index:
LILACS (Americas)
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2023
Type:
Article
Affiliation country:
Turkey
Institution/Affiliation country:
Ataturk University School of Medicine/TR
/
Health Sciences University/TR
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