Animal model of renal ischemic injury, and chlorpromazine protector effect, evaluate by tc-99m-mag3 dynamic renal scan

ABSTRACT

Acute tubular necrosis (ATN) is a major complication of kidney transplantation, so as of urologic and vascular surgeries. In transplantation, although organ perfusion with proper solution are feasible and at least partially effective, new approaches remains needed to avoid lost of graft function due to ischemic insults, and by this way, chlorpromazine may play this hole. Sixteen male rats were evaluated by scintigraphy (dynamic renal scan with Tc-99m-MAG3), before and after surgically promote ischemia of left kidney. Animals were divided in 3 groups Group A (control) without ischemic insult; Group B (ischemia without chlorpromazine) and Group C (ischemia with chlorpromazine). Group B demonstrated marked decreased of left renal function, compared with itself (right kidney; p 0,001) and compared with groups A and C (both p 0,001). No statistically observations was noted in group A, that makes sure of non-error source of surgical procedure lonely (p 0,05). Nevertheless mild decrease of left renal function was observed in some animals of group C, these appointments were not statistically significant (p 0,05). Further studies may prove, in the future, its usefulness in humans, specially concerning kidney transplantation.