The effectiveness of heparin, platelet-rich plasma (PRP), and silver nanoparticles on prevention of postoperative peritoneal adhesion formation in rats
Acta cir. bras
;
32(1): 2722-27, Jan. 2017. ilus
Article
in English
| LILACS, VETINDEX
| ID: biblio-1456230
ABSTRACT
Purpose:
To assess the effectiveness of heparin, platelet-rich plasma (PRP), and silver nanoparticles on prevention of postoperative adhesion in animal models.Methods:
Sixty males Albino Wistar rats aged 5 to 6 weeks were classified into five groups receiving none, heparin, PRP, silver nanoparticles, PRP plus silver nanoparticles intraperitoneally. After 2 weeks, the animals underwent laparotomy and the damaged site was assessed for peritoneal adhesions severity.Results:
The mean severity scores were 2.5 ± 0.9, 2.16 ± 0.7, 1.5 ± 0.5, 2.66 ± 0.88, and 2.25 ± 0.62 in the control, heparin, PRP, silver and PRP plus silver groups, respectively with significant intergroup difference (p = 0.004). The highest effective material for preventing adhesion formation was PRP followed by heparin and PRP plus silver. Moreover, compared to the controls, only use of PRP was significantly effective, in terms of adhesion severity (p = 0.01) .Conclusion:
Platelet-rich plasma alone may have the highest efficacy for preventing postoperative peritoneal adhesions in comparison with heparin, silver nanoparticles and PRP plus silver nanoparticles.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Peritoneum
/
Heparin
/
Platelet-Rich Plasma
/
Metal Nanoparticles
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Year:
2017
Type:
Article
Institution/Affiliation country:
Hamadan University of Medical Sciences/IR
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