Systemic effects induced by intralesional injection of ?-conotoxin MVIIC after spinal cord injury in rats
J. venom. anim. toxins incl. trop. dis
;
20: 1-6, 04/02/2014. tab, graf, ilus
Article
in English
| LILACS, VETINDEX
| ID: biblio-1484561
ABSTRACT
Calcium channel blockers such as conotoxins have shown a great potential to reduce brain and spinal cord injury. MVIIC neuroprotective effects analyzed in in vitro models of brain and spinal cord ischemia suggest a potential role of this toxin in preventing injury after spinal cord trauma. However, previous clinical studies with MVIIC demonstrated that clinical side effects might limit the usefulness of this drug and there is no research on its systemic effects. Therefore, the present study aimed to investigate the potential toxic effects of MVIIC on organs and to evaluate clinical and blood profiles of rats submitted to spinal cord injury and treated with this marine toxin. Rats were treated with placebo or MVIIC (at doses of 15, 30, 60 or 120 pmol) intralesionally following spinal cord injury. Seven days after the toxin administration, kidney, brain, lung, heart, liver, adrenal, muscles, pancreas, spleen, stomach, and intestine were histopathologically investigated. In addition, blood samples collected from the rats were tested for any hematologic or biochemical changes.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Wounds and Injuries
/
Bone Marrow
/
Calcium Channel Blockers
/
Conotoxins
/
Cerebrum
Limits:
Animals
Language:
English
Journal:
J. venom. anim. toxins incl. trop. dis
Year:
2014
Type:
Article
Institution/Affiliation country:
Universidade Federal de Minas Gerais/BR
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