Molecular aspects of the teratogenesis of rubella virus
Biol. Res
;
52: 47-47, 2019. ilus
Article
in English
| LILACS
| ID: biblio-1505767
ABSTRACT
Rubella or German measles is an infection caused by rubella virus (RV). Infection of children and adults is usually characterized by a mild exanthematous febrile illness. However, RV is a major cause of birth defects and fetal death following infection in pregnant women. RV is a teratogen and is a major cause of public health concern as there are more than 100,000 cases of congenital rubella syndrome (CRS) estimated to occur every year. Several lines of evidence in the field of molecular biology of RV have provided deeper insights into the teratogenesis process. The damage to the growing fetus in infected mothers is multifactorial, arising from a combination of cellular damage, as well as its effect on the dividing cells. This review focuses on the findings in the molecular biology of RV, with special emphasis on the mitochondrial, cytoskeleton and the gene expression changes. Further, the review addresses in detail, the role of apoptosis in the teratogenesis process.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pregnancy Complications, Infectious
/
Rubella
/
Rubella virus
/
Congenital Abnormalities
/
Rubella Syndrome, Congenital
/
Teratogenesis
Limits:
Female
/
Humans
/
Pregnancy
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
2019
Type:
Article
Affiliation country:
India
Institution/Affiliation country:
ICMR-National Institute of Virology/IN
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