LncRNA MALAT1 aggravates oxygen-glucose deprivation/reoxygenation-induced neuronal endoplasmic reticulum stress and apoptosis via the miR-195a-5p/HMGA1 axis
Biol. Res
;
54: 8-8, 2021. tab, ilus, graf
Article
in English
| LILACS
| ID: biblio-1505801
ABSTRACT
BACKGROUND:
This study aimed to investigate the potential role and molecular mechanism of lncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) in cerebral ischemia/reperfusion injury.RESULTS:
Using an oxygen-glucose deprivation/reoxygenation (OGD/R) cell model, we determined that the expression of MALAT1 was significantly increased during OGD/R. MALAT1 knockdown reversed OGD/R-induced apoptosis and ER stress. Mechanistically, MALAT1 promoted OGD/R-induced neuronal injury through sponging miR-195a-5p to upregulating high mobility group AT-hook1 (HMGA1).CONCLUSIONS:
Collectively, these data demonstrate the mechanism underlying the invovlvement of MALAT1 in cerebral ischemia/reperfusion injury, thus providing translational evidence that MALAT1 may serve as a novel biomarker and therapeutic target for ischemic stroke.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Reperfusion Injury
/
MicroRNAs
/
RNA, Long Noncoding
/
Adenocarcinoma of Lung
/
Lung Neoplasms
Limits:
Humans
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
2021
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
The First Affiliated Hospital of Harbin Medical University/CN
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