NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI-positive H. pylori
Biol. Res
;
54: 13-13, 2021. tab
Article
in English
| LILACS
| ID: biblio-1505806
ABSTRACT
BACKGROUND:
Helicobacter pylori is detected by pathogen recognition receptors including toll-like receptors (TLR) and nucleotide-binding oligomerization domain (NOD)-like receptors, eliciting an innate immune response against this bacteria. The aim of this study was to assess if polymorphisms of TLR2, TLR4, TLR5, NOD1 and NOD2 genes are associated with gastric cancer, in particular in individuals infected with H. pylori.RESULTS:
A case-control study of 297 gastric cancer patients and 300 controls was performed to assess the association of 17 polymorphisms. Analyses performed under the allele model did not find association with gastric cancer. However, NOD1 rs2075820 (p.E266K) showed association with intestinal-type gastric cancer among H. pylori infected subjects (OR = 2.69, 95% CI 1.41-5.13, p = 0.0026). The association was not statistically significant in diffuse-type gastric cancer cases (OR = 1.26, 95% CI 0.63-2.52, p = 0.51). When the analyses were performed in patients carrying H. pylori strains harboring the cag pathogenicity island (cagPAI), we noticed significant association with NOD1 rs2075820 (OR = 4.90, 95% CI 1.80-3.36, p = 0.0019), in particular for intestinal-type gastric cancer cases (OR = 7.16, 95% CI 2.40-21.33, p = 4.1 × 10- 4) but not among diffuse-type gastric cancer cases (OR = 3.39, 95% CI 1.13-0.10, p = 0.03).CONCLUSIONS:
NOD1 rs2075820 increases the risk of intestinal-type gastric cancer among individuals infected with H. pylori, particularly in those harboring the cagPAI.
Full text:
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Index:
LILACS (Americas)
Main subject:
Stomach Neoplasms
/
Helicobacter Infections
/
Nod1 Signaling Adaptor Protein
Type of study:
Observational study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
2021
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Barros Luco Hospital/CL
/
San Juan de Dios Hospital/CL
/
University of Chile Clinical Hospital/CL
/
University of Chile/CL
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