Your browser doesn't support javascript.
loading
Doxorubicin cardiotoxicity and Camellia sinensis cardioprotection determined by speckle-tracking echocardiography
Barreto, Maira Souza Oliveira; Carvalho, Juliana Lott; Melo, Marcos Barrouin; Michel, Ana Flávia Ribeiro Machado; Ferreira, Marina Guimarães; Muzzi, Ruthnéa Aparecida Lázaro; Goes, Alfredo Miranda de; Melo, Marilia Martins.
  • Barreto, Maira Souza Oliveira; Universidade Federal de Lavras. Departamento de Medicina Veterinária. Lavras. BR
  • Carvalho, Juliana Lott; Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte. BR
  • Melo, Marcos Barrouin; Universidade Federal de Minas Gerais. Departamento de Fisiologia e Farmacologia. Belo Horizonte. BR
  • Michel, Ana Flávia Ribeiro Machado; Universidade Estadual de Santa Cruz. Departamento de Ciências Agrárias e Ambientais. Ilhéus. BR
  • Ferreira, Marina Guimarães; Universidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia Veterinárias. Belo Horizonte. BR
  • Muzzi, Ruthnéa Aparecida Lázaro; Universidade Federal de Lavras. Departamento de Medicina Veterinária. Lavras. BR
  • Goes, Alfredo Miranda de; Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte. BR
  • Melo, Marilia Martins; Universidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia Veterinárias. Belo Horizonte. BR
Braz. J. Pharm. Sci. (Online) ; 59: e23063, 2023. tab, graf
Article in English | LILACS | ID: biblio-1505837
ABSTRACT
Abstract Doxorubicin (Dox) is a medication used in the treatment of cancerous tumors and hematologic malignancies with potentially serious side effects, including the risk of cardiotoxicity. Flavonoids are plant metabolites with antioxidant properties and can be extracted from Camellia sinensis (CS). The aim of this study is to evaluate the possible cardioprotective effect of CS against injuries induced by Dox in rats. A total of 32 animals were distributed into four groups (1) control - intraperitoneal injection (I.P.) of 0.5 mL saline weekly and 1.0 mL water by gavage daily; (2) CS - 0.5 mL saline I.P. weekly and 200 mg/kg CS by gavage daily; (3) Dox - 5.0 mg/kg Dox I.P. weekly and 1.0 mL water by gavage daily; and (4) Dox+CS -5.0 mg/kg Dox I.P. weekly and 200 mg/kg CS by gavage daily. Clinical examinations, blood profiles, electrocardiograms, echocardiograms, and histological analyses of hearts were performed over 25 days. The animals in the Dox group showed changes in body weight and in erythrogram, leukogram, electrocardiography, and echocardiography readings. However, animals from the dox+CS group had significantly less change in body weight, improved cardiac function, and showed more preserved cardiac tissue. This study demonstrated that CS prevents dox-induced cardiotoxicity, despite enhancing the cytotoxic effect on blood cells
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Doxorubicin / Camellia sinensis / Cardiotoxicity Limits: Animals Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2023 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Santa Cruz/BR / Universidade Federal de Lavras/BR / Universidade Federal de Minas Gerais/BR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Doxorubicin / Camellia sinensis / Cardiotoxicity Limits: Animals Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2023 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Santa Cruz/BR / Universidade Federal de Lavras/BR / Universidade Federal de Minas Gerais/BR