Egr-1 Enhances Drug Resistance of Breast Cancer Cells by MDR1 Dependence
Braz. J. Pharm. Sci. (Online)
;
59: e18705, 2023. graf
Article
in English
| LILACS
| ID: biblio-1505839
ABSTRACT
Abstract Paclitaxel (PTX) is one of the most effective drugs used in the treatment of breast cancer. Nonetheless, the appearance of MDR1 (multidrug resistance 1) in tumor cells has become a significant hindrance for efficacious chemotherapy. In this study, we show that the expression level of Egr-1 (early growth response gene-1) in cancer tissues (from paclitaxel chemotherapy failure patients) and MCF-7/PTX cells (the breast cancer cell line that was resistant to paclitaxel) was increased. Cell proliferation assay and apoptosis assay revealed that Egr-1 could promote cell growth and inhibit apoptosis in MCF-7/PTX. Mechanistic studies indicated that Egr-1 could bind to the proximal MDR1 promoter and enhance MDR1 transcription. These findings indicate that paclitaxel induced Egr-1 accumulation and upregulated the expression of MDR1, thereby inducing the drug resistance in MCF-7/PTX. Our results suggest a novel pathway by which paclitaxel induces MDR1 expression, possibly illuminating a potential target pathway for the prevention of MDR1-mediated drug resistance.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Breast Neoplasms
/
Drug Resistance
/
ATP Binding Cassette Transporter, Subfamily B, Member 1
Language:
English
Journal:
Braz. J. Pharm. Sci. (Online)
Journal subject:
Farmacologia
/
Teraputica
/
Toxicologia
Year:
2023
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Xuzhou Health Hospital of Women and Children/CN
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