Association between hyperuricemia and hypertension and the mediatory role of obesity: a large cohort study in China
Rev. Assoc. Med. Bras. (1992, Impr.)
;
69(8): e20220241, 2023. tab, graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1507306
ABSTRACT
SUMMARY OBJECTIVE:
This study aimed to investigate the sex-specific association between hyperuricemia and the risk of hypertension and whether obesity mediates this association.METHODS:
This study included 31,395 (47.0% women) adults without hypertension, cardiovascular disease, or cancer at baseline who completed at least one follow-up annual examination between 2009 and 2016. Cox regression models were performed to calculate hazard ratios and 95% confidence intervals. Mediation analysis was conducted to estimate the effect of body mass index on the association between hyperuricemia and hypertension.RESULTS:
During a median 2.9-year follow-up, hyperuricemia was significantly associated with a higher risk of hypertension (HR 1.15, 95%CI 1.07-1.24 for all participants; HR 1.12, 95%CI 1.03-1.22 for men; and HR 1.23, 95%CI 1.02-1.48 for women) after adjustment for potential confounders. Additional adjustment for body mass index attenuated this association (HR 1.09, 95%CI 1.08-1.10 for all participants; HR 1.07; 95%CI 0.98-1.16 for men; HR 1.18; 95%CI 0.96-1.44 for women). Mediation analysis showed that BMI partially mediated the relationship between hyperuricemia and incident hypertension (indirect effect HR 1.09, 95%CI 1.08-1.10; direct effect HR 1.08, 95%CI 1.02-1.15). The percentage of the mediation effect was 53.2% (95%CI 37.9-84.5).CONCLUSION:
Hyperuricemia is associated with a risk of hypertension in both sexes, and BMI partially mediates hyperuricemia-related incident hypertension.
Full text:
Available
Index:
LILACS (Americas)
Type of study:
Etiology study
/
Observational study
/
Risk factors
Language:
English
Journal:
Rev. Assoc. Med. Bras. (1992, Impr.)
Journal subject:
EducaÆo em Sa£de
/
GestÆo do Conhecimento para a Pesquisa em Sa£de
/
Medicine
Year:
2023
Type:
Article
/
Project document
Affiliation country:
China
Institution/Affiliation country:
Beijing Xiaotangshan Hospital/CN
/
Shenzhen Nanshan Center for Chronic Disease/CN
/
Shenzhen University/CN
Similar
MEDLINE
...
LILACS
LIS