Infections in patients with chronic lymphocytic leukemia
Hematol., Transfus. Cell Ther. (Impr.)
;
45(3): 387-393, July-Sept. 2023. tab
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1514164
ABSTRACT
ABSTRACT Introduction:
Infection is a major complication in patients with chronic lymphocytic leukemia (CLL). Newly diagnosed patients are at high risk of developing infection caused by encapsulated bacteria, such as Streptococcus pneumoniae and Haemophylus influenzae. Method andResults:
However, once treatment is initiated, the spectrum of pathogens causing infection broadens, depending on the treatment regimens. With disease progression, cumulative immunosuppression occurs as a consequence of multiple treatment lines and the risk of infection further increases. On the other hand, the use of targeted therapies in the treatment of CLL have brought new risks of infection, with an increased incidence of invasive fungal diseases, particularly aspergillosis, in patients receiving Bruton kinase inhibitors.Conclusion:
In this article, we review the epidemiology of infection in patients with CLL, taking into account the treatment regimen, and briefly discuss the management of infection.
Full text:
Available
Index:
LILACS (Americas)
Language:
English
Journal:
Hematol., Transfus. Cell Ther. (Impr.)
Journal subject:
Hematologia
/
TransfusÆo de Sangue
Year:
2023
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal do Rio de Janeiro (UFRJ)/BR
Similar
MEDLINE
...
LILACS
LIS