Your browser doesn't support javascript.
loading
Expression of Serum Vascular Endothelial Growth Factor and Angiopoietin Receptor Tie-2 in Essential Hypertension
Filiz, AK; Ozdemir, E; Gunes, H; Yılmaz, MB.
  • Filiz, AK; Sivas Cumhuriyet University. School of Medicine. Department of Physiology. Sivas. TR
  • Ozdemir, E; Sivas Cumhuriyet University. School of Medicine. Department of Physiology. Sivas. TR
  • Gunes, H; Sivas Cumhuriyet University. School of Medicine. Department of Physiology. Sivas. TR
  • Yılmaz, MB; Sivas Cumhuriyet University. School of Medicine. Department of Cardiology. Sivas. TR
West Indian med. j ; 69(7): 464-470, 2021. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1515708
ABSTRACT
ABSTRACT

Objective:

To investigate the serum levels of a vascular endothelial growth factor (VEGF), an angiogenic factor and a soluble angiopoietin receptor Tie-2 (sTie-2) in patients with essential hypertension.

Methods:

In the present study 90 individuals (56 males and 34 females, mean age 48 ± 7 years) have been divided into 3 groups 30 patients with hypertension, 30 healthy individuals with a family history of hypertension and 30 healthy individuals with no family history of hypertension. All individuals have been evaluated in terms of blood pressure and biochemical parameters. The levels of VEGF and Tie-2 receptor have been evaluated by using the enzyme-linked immunosorbent assay method.

Results:

The findings suggested that the serum VEGF, sTie-2 receptor, low-density lipoprotein and triglycerides levels in the hypertensive patients were significantly higher than those in the control group (p < 0.05). However, the level of high-density lipoprotein cholesterol in the patients was significantly lower than in those in the control group (p < 0.05). In correlation analysis, a positive correlation was found statistically significant between the values of VEGF and sTie-2 (r = 0.405, p = 0.026).

Conclusion:

As a result of this study, our data indicate that serum levels of VEGF and Tie-2 receptor may be related to the primary hypertension. This study could inspire to further studies to explore the roles of VEGF and Tie-2 receptor in essential hypertension.


Full text: Available Index: LILACS (Americas) Language: English Journal: West Indian med. j Journal subject: Medicine Year: 2021 Type: Article / Project document Affiliation country: Turkey Institution/Affiliation country: Sivas Cumhuriyet University/TR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Language: English Journal: West Indian med. j Journal subject: Medicine Year: 2021 Type: Article / Project document Affiliation country: Turkey Institution/Affiliation country: Sivas Cumhuriyet University/TR