Efficacy and safety of medical cannabinoids in children with cerebral palsy: a systematic review
Einstein (Säo Paulo)
;
21: eRW0387, 2023. tab, graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1520861
ABSTRACT
ABSTRACT Introduction The increasing popularity of cannabinoids for treating numerous neurological disorders has been reported in various countries. Although it reduces tetrahydrocannabinol psychoactivity, it helps patients tolerate higher doses and complements the anti-spasmodic effects of tetrahydrocannabinol. One of the most important potential of cannabinoids are related to its potential to help children with cerebral palsy, a contributor of lifelong disability. Therefore, this systematic review aimed to assess the efficacy and safety of medical cannabinoids in children with cerebral palsy. Methods This review adhered to The Preferred Reporting Items for Systematic Reviews and Meta-analysis 2020 guidelines. Seven databases, namely, Scopus, PubMed, EBSCO Host, ProQuest, Google Scholar, Semantic Scholar, and JSTOR, were used to identify relevant studies. Studies examining pediatric patients with cerebral palsy and reporting the efficacy and safety of medical cannabinoids through clinical trials, observational cross-sectional studies, or cohort designs were included. The outcomes of the studies included the efficacy of medical cannabinoids administered for spasticity, motor components, pain control, sleep difficulties, adverse effects, and seizure control. Results Of 803 identified articles, only three met the inclusion criteria for data synthesis. One study exhibited a moderate risk-of-bias. A total of 133 respondents, mainly from Europe, were investigated. Overall effectiveness and safety were considered good. However, the results are inconsistent, especially regarding spasticity treatment variables. Conclusion The anti-spasticity, anti-inflammatory, and anti-seizure properties of cannabinoids might be beneficial for patients with cerebral palsy, although their effectiveness has not been widely studied. Further studies with larger sample sizes and various ethnicities are warranted. Prospero database registration (www.crd.york.ac.uk/prospero) under ID CRD42022358383.
Full text:
Available
Index:
LILACS (Americas)
Type of study:
Systematic reviews
Language:
English
Journal:
Einstein (Säo Paulo)
Journal subject:
Medicine
Year:
2023
Type:
Article
Affiliation country:
Indonesia
Institution/Affiliation country:
Atma Jaya Catholic University of Indonesia/ID
/
Indonesia National Research and Innovation Agency/ID
/
Jakarta Anti-Aging Center Clinic/ID
/
Sriwijaya University/ID
/
Universitas Kristen Indonesia/ID
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