Serum and urinary angiotensinogen levels as prognostic indicators in acute kidney injury: a prospective study
Rev. Assoc. Med. Bras. (1992, Impr.)
;
69(12): e20230716, 2023. tab
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1521496
ABSTRACT
SUMMARY OBJECTIVE:
The delayed increase in serum creatinine levels poses challenges in the timely diagnosis of acute kidney injury. This study aimed to investigate the relationship between serum angiotensinogen and urinary angiotensinogen levels and the prognosis of renal function in patients diagnosed with acute kidney injury.METHODS:
A total of 79 newly diagnosed acute kidney injury patients aged 18 years and older were enrolled. Serum angiotensinogen and urinary angiotensinogen levels were measured at the onset of the disease, as well as on the 15th and 30th days of follow-up. After 3 months, renal function was evaluated by measuring serum creatinine levels.RESULTS:
Among the acute kidney injury patients, those in Kidney Disease Improving Global Outcomes stage 3 exhibited significantly higher urinary angiotensinogen/urine creatinine levels compared with stages 1 and 2 patients at the time of diagnosis (p<0.05). Furthermore, a positive correlation was observed between the urinary angiotensinogen/urine creatinine level at the time of diagnosis and the serum creatinine level at the third month (r=0.408, p=0.048).CONCLUSION:
The findings suggest that urinary angiotensinogen levels can serve as an indicator of the severity of acute kidney injury. Monitoring urinary angiotensinogen levels could potentially contribute to the prognosis assessment and management of acute kidney injury patients.
Full text:
Available
Index:
LILACS (Americas)
Language:
English
Journal:
Rev. Assoc. Med. Bras. (1992, Impr.)
Journal subject:
EducaÆo em Sa£de
/
GestÆo do Conhecimento para a Pesquisa em Sa£de
/
Medicine
Year:
2023
Type:
Article
Affiliation country:
Turkey
Institution/Affiliation country:
Şanlıurfa Mehmet Akif İnan Training and Research Hospital/TR
/
Samsun Training and Research Hospital/TR
/
Tokat Gaziosmanpaşa University Hospital/TR
Similar
MEDLINE
...
LILACS
LIS