Antibacterial and antifungal activity of curcumin and methylene blue associated with laser on bacterial and fungal strains
Rev. Ciênc. Saúde
;
13(4): 33-37, Dezembro 2023.
Article
in English
| LILACS
| ID: biblio-1526387
ABSTRACT
Objective:
To analyze the effect of methylene blue and 10% curcumin in fungi and bacteria through an in vitrostudy using photodynamic therapy (PDT).Methods:
Curcumin and methylene blue were photosensitized by a Photon Lase III laser applied for 90 s in a dark environment within a laminar flow chamber. Enterococcus faecalisand Candida albicans strains were cultured and standardized.Then, a minimum inhibitoryconcentration (MIC) assay was conducted for these photosensitizers, with concentration variations and incubation to evaluate their antimicrobial activity.Results:
With PDT, Curcumin had significant antibacterial activity against E. faecalis (MIC = 250 µg/mL).In contrast, methylene blue had antibacterial activity against E. faecalis (MIC < 12.5 µg/mL with PDT) and antifungal activity against C. albicans (MIC <12.5 µg/mL with or without PDT).Both agents showed greater efficacy in the presence of the laser.The results suggest that curcumin and methylene blue associated with laser may effectively treat microbial infections.Conclusion:
Further research is needed to evaluate the efficacy and safety of using these agents in animal and human models and theireffectiveness against different bacterial and fungal strains.
Full text:
Available
Index:
LILACS (Americas)
Type of study:
Risk factors
Language:
English
Journal:
Rev. Ciênc. Saúde
Journal subject:
Cincias da Sa£de
/
Medicina
Year:
2023
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Institute of Higher Education of Vale do Parnaíba/BR
/
Parnaiba Delta Federal University/BR
/
State University of Piauí/BR
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