Sialic acid as the potential link between lipid metabolism and inflammation in the pathogenesis of atherosclerosis
Braz. j. med. biol. res
;
56: e12972, 2023.
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1528098
ABSTRACT
In the modern world, cardiovascular diseases have a special place among the most common causes of death. Naturally, this widespread problem cannot escape the attention of scientists and researchers. One of the main conditions preceding the development of fatal cardiovascular diseases is atherosclerosis. Despite extensive research into its pathogenesis and possible prevention and treatment strategies, many gaps remain in our understanding of this disease. For example, the concept of multiple low-density lipoprotein modifications was recently stated, in which desialylation is of special importance. Apart from this, sialic acids are known to be important contributors to processes such as endothelial dysfunction and inflammation, which in turn are major components of atherogenesis. In this review, we have collected information on sialic acid metabolism, analyzed various aspects of its implication in atherosclerosis at different stages, and provided an overview of the role of particular groups of enzymes responsible for sialic acid metabolism in the context of atherosclerosis.
Full text:
Available
Index:
LILACS (Americas)
Type of study:
Etiology study
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2023
Type:
Article
/
Project document
Affiliation country:
RUSSIA
Institution/Affiliation country:
Federal State Budgetary Scientific Institution, Petrovsky National Research Centre of Surgery (FSBSI Petrovsky NRCS)/RU
/
Institute for Atherosclerosis Research/RU
/
Moscow Regional Research and Clinical Institute (MONIKI)/RU
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