Single Nucleotides Polymorphisms in COX2 Gene and their Association with Signs and Symptoms of Teething - A Pilot Study
Pesqui. bras. odontopediatria clín. integr
;
23: e210244, 2023. tab, graf
Article
in English
| LILACS, BBO
| ID: biblio-1529121
ABSTRACT
ABSTRACT Objective:
To investigate the association between single nucleotide polymorphisms in the COX2 gene (rs689466 and rs5275) and local and systemic signs and symptoms of teething. Material andMethods:
Forty-four pairs of mothers-babies/toddlers were included. Erupted primary teeth were evaluated during clinical examination. Local and systemic signs and symptoms of teething were obtained from mothers' reporting via anamnesis. Samples of buccal cells were retrieved for DNA genotyping using real-time PCR. The T-test, Chi-square test, logistic regression, and haplotype analyses were applied.Results:
Almost all mothers (95.5%) reported at least one local or systemic sign and symptom of teething. The most common was increased salivation (79.5%), diarrhea (72.3 %), and fever (70.5 %). The mean number of signs and symptoms per child was higher in boys than girls (mean = 5.1; SD= 1.5; p=0.008). Sleep disturbance (p=0.03) and loss of appetite (p=0.05) were more reported in boys. The rs689466 and rs5275 were not associated with signs and symptoms of teething (p>0.05).Conclusion:
The single nucleotide polymorphisms in the COX2 gene (rs689466 and rs5275) were not associated with local and systemic signs and symptoms of teething.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Sleep Wake Disorders
/
Tooth, Deciduous
/
Tooth Eruption
/
Polymorphism, Single Nucleotide
Type of study:
Diagnostic study
/
Risk factors
Limits:
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
English
Journal:
Pesqui. bras. odontopediatria clín. integr
Journal subject:
Dentistry
Year:
2023
Type:
Article
Affiliation country:
Brazil
/
Germany
Institution/Affiliation country:
Federal University of Alfenas/BR
/
Positivo University/BR
/
University Hospital Regensburg/DE
/
University of the Region of Joinville/BR
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